摘要
索戈托病毒属于正黏病毒家族,是一种由蜱传播给人或动物的虫媒病毒,其基因结构特征、复制及转录、编码产物的功能等与流感病毒有诸多相似之处,对流感病毒保守位点的探究具有重要意义,而且索戈托病毒属病毒的动物模型有望作为人感染高致病性流感病毒的一个替代模型。不过迄今为止全球对索戈托病毒的研究尚少,尚未引起足够的重视。本文主要对索戈托病毒的分类、基因组成及各基因编码产物、进化特点等进行了介绍,重点总结了其第六个基因片段编码的基质蛋白M和ML蛋白在病毒复制周期中所发挥的作用以及病毒与宿主间的相互作用机制等方面的研究进展。
Thogoto virus belongs to the family Orthomyxoviridae. It is a tick-borne arbovirus that can infect both human and animals. Thogoto viruses genetic constitution, replication and transcription, and the func- tion of the translated proteins are similar to influenza virus. The studies on Thogoto virus are important for us to better understand the conservative sites of influenza virus. Moreover, the animal model of Thogo- to virus is expected to be an alternative model for highly pathogenic influenza viruses. In the past years, Thogoto virus attracted limited public attention and few studies were engaged in this area. The classifica- tion of Thogoto virus, the genetic constitution and evolution, and viral proteins were included in this re- view. The functions of M protein and ML protein were emphasized, which were translated from the sixth segment and played an important role in viral replication, the interaction between Thogoto virus and host were also highlighted.
出处
《病毒学报》
CAS
CSCD
北大核心
2013年第5期555-558,共4页
Chinese Journal of Virology
基金
国家科技重大专项项目“重大传染病应急处置检测技术平台”(2013ZX10004-101)
