摘要
目的:通过应用经阴道彩色多普勒超声(TVS)检测原发性卵巢癌阻力指数(RI)并联合肿瘤标志物(CA125、CA153)检测,分析其与原发性卵巢癌临床分期的关系,探讨二联(RI+CA125、RI+CA153)和三联(RI+CA125+CA153)检测对临床早期(Ⅰ期和Ⅱ期)原发性卵巢癌的诊断价值。方法 :回顾性总结原发性卵巢癌52例,按照国际妇产科联盟(FIGO)分期标准分期,Ⅰ期10例,Ⅱ期12例,Ⅲ期20例,Ⅳ期10例。将各期RI、CA125、CA153及二联(RI+CA125、RI+CA153)和三联(RI+CA125+CA153)检测结果,进行统计学分析。结果:原发性卵巢癌RI、CA125、CA153在Ⅰ期和Ⅱ期间比较差异无统计学意义(P>0.05),而在Ⅲ期、Ⅳ期与Ⅰ期、Ⅱ期间比较差异有统计学意义(P<0.05);RI、CA125在Ⅲ期与Ⅳ期间比较差异有统计学意义(P<0.05);CA153在Ⅲ期与Ⅳ期间比较差异无统计学意义(P>0.05)。原发性卵巢癌Ⅰ期和Ⅱ期,三联检测与单项检测阳性率比较差异有统计学意义(P<0.05),二联检测与单项检测阳性率比较差异无统计学意义(P>0.05);在Ⅲ期,三联和二联检测与CA153单项检测阳性率比较差异均有统计学意义(P<0.05),而与RI、CA125阳性率比较差异均无统计学意义(P>0.05);在Ⅳ期,三联和二联检测与单项检测阳性率比较差异均无统计学意义(P>0.05)。结论:三联检测有助于提高早期原发性卵巢癌(Ⅰ期和Ⅱ期)的检出率、降低漏诊率,三联检测对原发性卵巢癌早期有较高的诊断价值。
Objective：To evaluate the diagnostic value of coupled （RI ＋ CA125, RI ＋ CAls3） and tripled （RI ＋CA125 ＋ CA153） measurements on screening early stage of primary ovarian cancer（stages I and II） employing resistance index（RI） obtained from transvaginal color Doppler sonography（I-VS） and blood tumor markers （CA 125, CA 153 ）. Methods：Totally 52 patients with primary ovarian cancer were enrolled in this study. Based on the International Federation of gynecology and Obstetrics （FIGO） diagnostic criteria, 10,12,20 and 10 cases were diagnosed as stages I, ]I, m, and IV, respectively. Patients in the same stage were assorted into one group. According to retrospective reviews, the single （ RI, CA125, CA153 ）, coupled （ RI ＋ CA125, RI ＋ CA153 ） and tripled （ RI ＋ CA125 ＋ CA 153 ） measurements were further analyzed statistically. Results： RI, CA 125 and CAls3 did not present statistical differences in patients with stages I and Ⅱ primary ovarian cancer（ P 〉 0. 05） ,but did show significant changes in stages Ⅲ and IV patients （ P 〈 0.05） ; RI and CA125, but not CAl~,exhibited statistical difference between stage II1 and stage IV patients（ P 〈0. 05）. Tripled measure- ment significantly increased the positive rate as compared to single measurement （ P 〈 0.05 ）, however no difference was found between single and coupled measurement in patients with stages [ and Ⅱ primary ovarian cancer（ P 〉 0. 05）. In stage Ⅲ patients,there was difference between coupled-and tripled-measurement and CAI （P〈0.05）, but not the RI and CA125 （P 〉 0.05）. In stage Ⅳ patients,there was no differ-ence between coupled-and tripled-measurements and single testing（ P 〉 0.05）. Conclusions： Tripled measurement is helpful to improve the early primary ovarian cancer（stage Ⅰ and stage Ⅱ ） detection rate,to reduce the missed diagnosis,Tripled measurement of primary ovarian cancer has a high diagnostic value.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2013年第9期691-694,共4页
Journal of Practical Obstetrics and Gynecology
