摘要
目的探讨解脲脲支原体(Uu)、沙眼衣原体(Ct)感染与宫颈糜烂的关系并指导临床预防、治疗。方法采用培养、鉴定、药敏一体化试剂盒及免疫层析法对200例宫颈糜烂患者(观察组)和200例健康对照者(对照组)的宫颈分泌物进行解脲脲支原体、沙眼衣原体的检测,比较两组解脲脲支原体、沙眼衣原体的检出阳性率并根据糜烂程度进行分析,对支原体培养测定结果阳性者行药敏试验。结果观察组解脲脲支原体、沙眼衣原体阳性率分别为50.5%、23.5%,对照组解脲脲支原体、沙眼衣原体阳性率分别为18.5%、6.5%,两组阳性率比较差异有统计学意义(P<0.01);试验组轻度宫颈糜烂患者解脲脲支原体阳性率31.3%,中度宫颈糜烂患者解脲支原体阳性率58.5%,重度宫颈糜烂患者解脲脲支原体阳性率73.7%,组间比较差异有统计学意义(P<0.05);两组支原体属阳性患者的药物敏感率分别为克拉霉素96.6%、米诺环素61.6%、多西环素60.6%、阿奇霉素53.3%、罗红霉素49.9%、氧氟沙星31.9%。结论宫颈糜烂患者解脲脲支原体、沙眼衣原体感染率明显升高,宫颈糜烂程度越重解脲脲支原体、沙眼衣原体感染率越高,支原体属药物敏感试验以克拉霉素为最敏感。
OBJECTIVE To investigate the relationship between the Ureaplasma urealyticum （Uu）, Chlarnydia trachomatis （Ct） infections and the cervical erosion so as to guide the clinical prevention and treatment. METHODS The culture, identification, and susceptibility integration kit, and immunochromatography were employed to detect the cervical secretions obtained from 200 cases of cervical erosion patients （ the observation group） and 200 healthy controls （ the eontrol group） for the Uu and Ct. The positive rates of the Uu and Ct were compared between the two groups and were analyzed according to the extent of erosion. The drug susceptibility testing was performed for the patients with Mycoplasma tested positive. RESULTS In the observation group, the positive rate of Uu was 50.5%, Ct 23.5% ; in the control group, the positive rate of Uu was 18.5%, Ct 6.5%, the difference in the positive rate between the two groups was statistically significant （P〈0.01）. In the observa- tion group ,the positive rate of Uu was 31.3% in the patients with mild cervical erosion, 58.5%% in the patients with moderate cervical erosion, and 73.7% in the patients with severe cervical erosion , the difference was statisti- cally significant （P〈0.05）. For the patients with Mycoplasma tested positive in the two groups, the drug suscep- tibility rate to clarithromyein was 96.6 %, minoeyeline 61.6 %, doxycycline 60.6 %, azithromycin 53.3 %, rox- ithromycin 49.9%, and ofloxacin 31.90/00. CONCLUSION The incidence rate of the Uu or Ct infections is signifi- cantly elevated in the patients with cervical erosion, and the more severe the infections are, the higher the inci- dence of Uu or Ct infections. The drug susceptibility testing shows that the Mycoplasma are most sensitive to clar- ithromycin.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第15期3680-3681,共2页
Chinese Journal of Nosocomiology
关键词
宫颈糜烂
解脲脲支原体
沙眼衣原体
感染
Cervical erosion
Ureaplasma ureal yticum
Chlamydia trachomatis
Infection
