摘要
目的：探讨首发青年抑郁症患者海马脑区神经生化代谢物的变异情况以及与记忆功能的相关关系。方法：对20例首发青年抑郁症患者（患者组）应用质子磁共振波谱（1H-MRS）检查，测量海马脑区神经生化代谢物N-乙酰天门冬氨酸（NAA）、胆碱复合物（Cho）、肌酸（Cr）、肌醇（mI）的含量，同时采用韦氏记忆量表（WMS）测评进行认知心理学评定，并与15例健康对照者（对照组）进行比较。结果：①患者组记忆商数（89．15±6．62）分，较对照组明显降低（P〈0．01），长时记忆、短时记忆和瞬时记忆三方面均明显受损（P〈0．05～0．01）；②患者组左侧海马NAA／Cr比值（1．34±0．08）较对照组明显降低（P〈0．01），双侧海马mI／Cr比值分别为0．63±0．13和0．6±0．1较对照组均有增高（P〈0．05）；③患者组左侧NAA／Cr与记忆商数呈正相关（P〈0．01），左侧mL／Cr与记忆商数呈负相关（P〈0．05）。结论：首发青年抑郁症存在记忆功能障碍和海马神经细胞代谢功能异常，左侧海马脑区NAA／Cr降低和mlfCr增高，可能是首发青年抑郁症记忆障碍的病理生理机制之一。
Objective： To investigate the correlation of neurochemical metabolism in hippocampus with memory function in young adult patients with first-episode depression. Methods： Twenty patients with first-episode depression （patient group） and fifteen health subjects （control group） were enrolled in the study. The neurochemical metabolism, including the levels of N-acetylaspartate （ NAA ）, Choline （Cho）, Creatine （Cr）, Myoinositol （mI） were measured by proton magnetic resonance spectroscope （ 1 H-MRS） in bilateral hippocampus. Wechsler Memory Scale （WMS） were used to examine the memory function in both groups. Results： The memory quotient （89. 15±6. 62 ） of patient group was significantly lower than that of controls （P 〈 0.01 ）, the scores of long-term memory, short-term memory and immediate memory in patients were also lower than those of controls （P 〈0.05 or 0.01 ）. In patient group, the ratio of NAA/Cr （ 1.34±0.08 ） in the left hippocampus was significantly lower than that of control group （P 〈0.01 ） ; and the ratio of mI/Cr in the bilateral hippocampus [ （0.63 ± 0.13 ） in left and （0.6 ±0.1 ） in right ] was significantly higher than those in control group （ P 〈 0.05 ）. In patient group,the ratio of NAA/Cr in the left hippocampus was positively correlated with WMS scores （P 〈 0. 01 ）, and the ratio of mI/Cr in the left hippocampus was negatively correlated with WMS scores （ P 〈 0. 05 ）. Conclusion： The memory deficit and abnormal metabolism function of neuron cell in hippocampus coexist in young adult patients with first-episode depression, and the lower NAA/Cr and higher mI/Cr ratio in the left hippocampus may result in the memory deficit.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2013年第4期450-455,共6页
Journal of Zhejiang University(Medical Sciences)
基金
浙江省公益技术研究社会发展基金资助项目(2012C33119)
浙江省教育厅科研基金资助项目(Y201017558)
浙江省医药卫生科学研究基金资助项目(2012KYB095)
关键词
抑郁症
放射性核素显像
海马
病理生理学
记忆障碍
磁共振波谱学
记忆功能
海马
Depressive disorder/radionuclide imaging
Hippocampus/physiopathology
Memory disorders
Magnetic resonance spectroscopy
Memory function
Hippocampus
