摘要
目的了解新生儿患者多重耐药菌社区感染的特点和定植情况,采取预防控制措施,防止在院内传播。方法对2011年9月-2012年8月所有新入院新生儿患者共801例进行耐甲氧西林金黄色葡萄球菌(MRSA)、耐万古霉素肠球菌(VRE)和产超广谱β内酰胺酶(ESBL)菌入院筛查,了解多重耐药菌社区感染的特点和定植情况。并将801例新生儿患者(观察组)医院感染发生率与2010年9月-2011年8月同期801例新生儿患者(对照组)医院感染发生率进行比较。结果观察组发现MRSA和产ESBL菌共321例,检出率为40.1%。其中包括单纯MRSA 45例,占14.1%;产ESBL菌238例,占74.1%;MRSA+产ESBL菌38例,占11.8%。观察组医院感染发生率为2.0%,多重耐药菌医院感染构成比为12.5%;对照组医院感染发生率为5.1%,多重耐药菌医院感染构成比为53.6%;两组医院感染发生率和多重耐药菌医院感染构成比差异均有统计学意义(P<0.01)。结论新生儿患者多重耐药菌定植情况严重,应引起高度重视,加强管理可防止在医院传播,减少医院感染发生。
Objective To understand the characteristics of multidrug-resistant bacteria infection in neonatal patients,in order to take measures to prevent and control nosocomial transmission.Methods Admission screening for methicillin-resistant Staphylococcu aureus（MRSA）,vancomycin-resistant enterococcus（VRE） and extended-spectrum beta-lactamases（ESBLs）-producing organisms was carried out for 801 neonatal patients treated in our hospital between September 2011 and August 2012 to understand multidrug resistant bacteria infection characteristics and colonization situation.And hospital infection rate of these patients（experimental group） was compared with that of another 801 neonatal patients（control group） treated between September 2010 and August 2012 in our hospital.Results The experimental group had 321 cases of MRSA and ESBLs-producing organisms with a detection rate of 40.1%,including 45 cases of simple MRSA accounting for 14.1%,and 238 cases of ESBLs-producing organisms accounting for 74.1%.There were 38 cases of MRSA combined with ESBLs-producing organisms,accounting for 11.8%.The hospital infection rate and multidrug resistant bacteria infection constituent ratio among the whole hospital infection cases were 2.0% and 12.5% for the experimental group,and 5.1% and 53.6% for the control group,and the differences were statistically significant（P0.01）.Conclusions Multidrug resistant bacteria infection and colonization situation is serious for neonatal patients.We should pay high attention on this and strengthen management to prevent hospital transmission and reduce hospital infection.
出处
《华西医学》
CAS
2013年第8期1149-1151,共3页
West China Medical Journal
关键词
新生儿
多重耐药菌
社区感染
入院筛查
Neonate
Multidrug resistant bacteria
Community infection
Admission screening
