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老年急性髓系白血病的治疗现状 被引量:1

On therapy of acute myelogenous leukemia therapy in the elderly
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摘要 急性髓系白血病(AML)随着年龄的增长发病率逐渐升高。由于老年AML患者化疗完全缓解率低,治疗相关死亡率高,长期生存率低,预后差,尚缺乏统一有效的治疗策略。本文就目前老年AML治疗现状作简单综述,探讨传统化疗、造血干细胞移植及新的靶向药物在老年AML治疗中的应用。 The incidence of acute myelogenous leukemia (AML) increases with aging. Due to the low complete remission rate and high treatment-related mortality and the poor prognosis, there is lack of unified and effective therapeutic strategies for elderly patients with AML. In this paper, we reviewed the current situation on treatment of AML in the elderly, including the roles of conventional chemotherapy, allogeneic stem cell transplantation and some novel targeted agents.
出处 《中华老年多器官疾病杂志》 2013年第8期561-564,共4页 Chinese Journal of Multiple Organ Diseases in the Elderly
关键词 白血病 髓系 急性 老年人 治疗 leukemia, myelogenous, acute elderly therapy
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  • 1Grimwade D, Walker H, Harrison G, et al. The predictive value of hierarchical cytogenetic classification in older adults with acute myelogenous leukemia(AML): analysis of 1065 patients entered in to the United Kingdom Medical Research Council AML11 trial[J]. Blood, 2001, 98(5): 1312-1320. 被引量:1
  • 2Leith CP, Kopecky KJ, Godwin J, et al. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study[J]. Blood, 1997, 89(9): 3323-3329. 被引量:1
  • 3Gajewski JL, Ho WG, Nimer SD, et al. Efficacy of intensive chemotherapy for acute myelogenous leukemia associated with a preleukemic syndrome[J]. J Clin Oncol, 1989, 7(11): 1637-1645. 被引量:1
  • 4Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults : recommendations from an international expert panel, on behalf of the European LeukemiaNet[J]. Blood, 2010,115(3): 453-474. 被引量:1
  • 5Pinto A, Zagonel V, Ferrara F. Acute myeloid leukemia in the elderly: biology and therapeutic strategies[J]. Crit Rev Oncol Hematol, 2001, 39(3): 275-287. 被引量:1
  • 6Sekeres MA, Stone RM. The challenge of acute myeloid leukemia in older patients[J]. Curr Opin Oncol, 2002, 14(1): 24-30. 被引量:1
  • 7Rowe JM, Neuberg D, Friedenberg W, et al. A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group[J]. Blood, 2004, 103(2): 479-485. 被引量:1
  • 8Burnett AK, Milligan D, Prentice AG, et al. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment[J]. Cancer, 2007, 109(6): 1114-1124. 被引量:1
  • 9Lancet JE, Giralt S. Therapy for older AML patients: the role of novel agents and allogeneic stem cell transplant[J]. J Natl Compr Canc Netw, 2008, 6(10): 1017-1025. 被引量:1
  • 10Anderson JE, Kopecky KJ, Willman CL, et al. Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin:a Southwest Oncology Group study[J].Blood, 2002, 100(12): 3869-3876. 被引量:1

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