摘要
目的:比较左西替利嗪和西替利嗪治疗慢性荨麻疹的疗效。方法:选择90例慢性荨麻疹患者,根据用药不同分为左西替利嗪组和西替利嗪组,每组各45例,左西替利嗪组服用盐酸左西替利嗪5 mg/次,1次/d,西替利嗪组服用盐酸西替利嗪10 mg/次,1次/d。治疗28 d后,比较两组患者的临床疗效、荨麻疹症状体征评分及不良反应发生情况。结果:治疗28 d后左西替利嗪组的总有效率为88.89%,显著高于西替利嗪组的总有效率82.22%,差异有统计学意义(P>0.05);但痊愈率两组差异无统计学意义(P>0.05)。治疗结束后左西替利嗪组的风团直径、风团数量、发作持续时间、瘙痒程度评分均显著低于西替利嗪组,差异有统计学意义(P<0.05),左西替利嗪组有2例口干,3例轻度嗜睡,总不良反应发生率为11.11%,西替利嗪组有3例口干,严重嗜睡5例,总不良反应发生率为17.78%,两组差异有统计学意义。结论:采用左西替利嗪治疗慢性荨麻疹的临床疗效显著,不良反应发生率低。
Objective To compare the efficacy of left cefifizine and cinnarizine and in the treatment of chronic urtieariv. Method 90 patients with chronic urticaria were divided into the levocetirizine and cetifizine group, and each group with 45 patients. The levocetirizine group was taken with the hydrochloric levocetirizine 5 mg / time, and 1 time/d. The cetirizine group was taken the hydrochloric cetirizine 10 mg/ 1 / d. After treatment for 28 days, the clinical efiqcacy, urticaria signs and symptoms score and adverse events of the two groups were compared. Results The total effective rate after treatment for 28 days in the ]evocetirizine group was 88. 89%, significantly higher than the total effective rate of the cefirizlne group of 82. 22% （P 〉 0. 05 ）, the cure rate between the two groups was with no significant differ- ence, P 〈 0. 05. The wheal diameter, number of wheal, attack duration, itching scores of levocetirizine group after the treatment were signifi- cantly lower than cetirizine group,P 〈0. 05. There were 2 cases of mouth dry,3 cases of mild lethargy,and the total adverse reaction inci- dence was 11.11% in the levocetifizine group. There were 3 cases of dry mouth,5 cases of serious lethargy,the total adverse reaction rate was 17.78% in the cetirizine group,there had significant differences in the two groups. Conclusion The clinical effect of levocetirizine in the treatment of chronic urticaria is significant, and it is with a low incidence of adverse reactions.
出处
《吉林医学》
CAS
2013年第25期5133-5135,共3页
Jilin Medical Journal
