摘要
目的探讨氨氯地平联合氢氯噻嗪治疗老年人单纯收缩期高血压的效果,与单药氨氯地平治疗进行比较。方法选择96例老年单纯收缩期高血压患者,随机分成单药组46例,给氨氯地平口服,联合治疗组50例给氨氯地平和小剂量氢氯噻嗪口服。两组用药实行个体化治疗,并根据昼夜血压变化规律服药。结果单药治疗组显效28例(60.87%),有效8例(17.39%),总有效率78%,联合治疗组显效44例88%),有效6例(12%),总有效率100%。差异有统计学意义(P<0.05)。结论氨氯地平与噻嗪类利尿药合用使血压明显下降,可作为联合治疗老年收缩期高血压的理想药物,不良反应小,降压效果好,是门诊联合用药治疗老年人单纯收缩期高血压确切而有效的方法 。
Objective To investigate amlodipine hydrochlorothiazide effect the treatment of elderly patients with isolated systolic hypertension,compare single drug amlodipine treatment. Methods 96 elderly patients with isolated systolic hypertension,were randomly divided into single-drug group （ 46 cases） ,and to the oral administration of amlodipine amlodipine combination therapy group,50 patients peace of a small dose of hydrochlorothiazide oral. The two sets of medication to implement individualized treatment,and according to the circadian variation of blood pressure medication. Results Monotherapy group,28 cases （ 60. 87% ） markedly effective in 8 cases （ 17. 39% ） ,the total efficiency of 78% ,the joint treatment group,88% of the 44 cases） , effective in 6 cases （ 12% ） ,total efficiency of 100 % . The difference was statistically significant （ P 0. 0 （ P 0. 05） . Conclusion blood pressure decreased significantly,as the ideal drug for the joint treatment of elderly patients with systolic hypertension,adverse reaction of amlodipine and thiazide diuretics,lowering the pressure effect is precise and effective method of outpatient combination therapy in elderly patients with isolated systolic hypertension.
出处
《中国实用医药》
2013年第25期43-44,共2页
China Practical Medicine
关键词
单纯收缩期高血压
氨氯地平
氢氯噻嗪
Isolated systolic hypertension
Amlodipine
Hydrochlorothiazideo
