摘要
目的探讨羟基脲联合干扰素α-2b治疗慢性粒细胞白血病的临床疗效。方法收集2009年1月～2010年1月来我院治疗的慢性粒细胞白血病患者56例,根据治疗方法不同分为观察组30例和对照组26例,观察组予羟基脲联合干扰素α-2b治疗,对照组予羟基脲治疗,比较两组治疗后的总有效率、完全缓解率、临床症状体征消失时间及随访36个月后的急变率。结果观察组30例患者治疗后完全缓解率80.00%,明显高于对照组(69.23%),差异具有统计学意义(P<0.05)。观察组的总有效率93.33%,虽然高于对照组的总有效率80.77%,但差异无统计学意义(P>0.05)。观察组胸骨压痛消失时间、脾肿大肋缘下未触及时间、血常规及骨髓象恢复正常时间与对照组比较,差异具有统计学意义(P<0.05)。观察组CML急变率10%,低于对照组42.3%,差异具有统计学意义(P<0.05)。结论羟基脲联合干扰素α-2b治疗慢性粒细胞白血病疗效确切,安全性好,值得推广和应用。
Objective To investigate the clinical efficacy of hydroxyurea combined with interferon α-2b in treatment of chronic myeloid leukemia.Methods All 56 patients with chronic myeloid leukemia in our hospital according to the different treatment methods were divided into two groups,30 cases in the observation group,26 cases in the control group,the observation group treated with hydroxyurea and interferon α-2b treatment,control group was treated with hydroxyurea therapy,the total efficient rate,completed remission rate,clinical symptoms disappeared time and followed up for 36 months after the blast rate were compared between two groups.Results The complete remission rate was 80% in the observation group,was significantly higher than that in control group（69.23%） with significant difference（P 0.05）.The efficiency rate of the observation group was 93.33%,was higher than the the control group（80.77%）,but no statistically significant difference between two groups（P 0.05）.The observation group patients with sternal tenderness disappearing time,splenomegaly subcostal untouched time,blood and bone marrow recovery time compared with the control group with significant difference（P 0.05）.The observation group in blast crisis of CML was lower than the control group（P 0.05）.Conclusion Hydroxyurea combined with interferon α-2b in treatment of chronic myelogenous leukemia have good curative effect,security is good,and it is worthy of promotion and application.
出处
《中国现代医生》
2013年第25期47-48,共2页
China Modern Doctor
