摘要
目的观察血浆脑钠肽(BNP)水平与老年慢性心力衰竭(CHF)患者心功能分级的关系,探讨BNP在老年CHF早期诊断及预后评估中的临床应用价值。方法选择老年CHF患者183例(CHF组)和健康老年人62例(对照组),比较不同心功能分级老年CHF患者血浆BNP和心肌肌钙蛋白I(cTnI)水平,并分析老年CHF患者血浆BNP水平与左心室射血分数(LVEF)和左心室舒张末期内径(LVEDD)的关系。结果 CHF组心功能Ⅰ级患者血浆BNP水平与对照组比较差异无统计学意义(P>0.05),CHF组心功能Ⅱ、Ⅲ、Ⅳ级患者血浆BNP水平显著高于对照组(P<0.05),心功能Ⅰ、Ⅱ、Ⅲ、Ⅳ级患者血浆BNP水平两两比较差异均有统计学意义(P<0.05)。CHF组心功能Ⅰ、Ⅱ级患者cTnI水平与对照组比较差异均无统计学意义(P>0.05),CHF组心功能Ⅲ、Ⅳ级患者cTnI水平显著高于对照组(P<0.05),CHF组心功能Ⅲ、Ⅳ级患者cTnI水平显著高于心功能Ⅰ、Ⅱ级患者(P<0.05),CHF组心功能Ⅳ级患者cTnI水平显著高于心功能Ⅲ级患者(P<0.05),CHF组心功能Ⅰ、Ⅱ级患者cTnI水平比较差异无统计学意义(P>0.05)。CHF患者血浆BNP和cTnI水平与心功能分级均呈显著正相关(P<0.05)。血浆BNP水平与LVEDD呈显著正相关(P<0.05),而与LVEF呈显著负相关(P<0.05)。结论 BNP在老年CHF的诊断及预后评估中有重要的临床价值。
Objective To study the relationship between plasma brain natriuretic peptide （BNP） level and cardiac function classification in elderly patients with chronic heart failure （ CHF）, and to explore the clinical value of BNP in the early diagnosis and prognostic evaluation of elderly patients with CHF. Methods One hundred and eighty-three patients with CHF（ CHF group） and sixty-two healthy elderly people （control group） were selected, the levels of plasma BNP and cardiac troponin I（cTnI） in elderly CHF patients with different cardiac function classification were compared, and the relationship be- tween plasma BNP level and left ventricular ejection fraction （LVEF） or left ventricular end-diastolic dimension （LVEDD） in elderly patients with CHF was analyzed. Results There was no significant difference in plasma BNP level between the patients with heart function class I in CHF group and control group（P 〉 0.05） ;but the BNP level in patients with heart function class II , III and IV in CHF group was significantly higher than that in control group（P 〈0.05） ;there was significant difference in plasma BNP level among the CHF patients with heart function class I , II, ]]I and 1V by pairwise comparison （ P 〈 O. 05 ）. There was no significant difference in cTnI level between the patients with heart function class I , 11 in CHF group and control group（ P 〉 0.05 ） ; but the cTnI level in patients with heart function class III and IV in CHF group was significantly higher than that in control group（P 〈0.05）. In CHF group,the cTnI level in the patients with heart function class III and IV was signifi- cantly higher than that in the patients with heart function class I and II （P 〈 0.05） ; the cTnI level in the patients with heart function class IV was significantly higher than that in the patients with heart function class III （ P 〈 0. 05 ） ; but there was no significant difference in cTnI level between the patients with heart function class I and the patients wi
出处
《新乡医学院学报》
CAS
2013年第9期741-743,共3页
Journal of Xinxiang Medical University
关键词
慢性心力衰竭
心功能分级
脑钠肽
chronic heart failure
heart function class
brain natriuretic peptide
