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七氟醚预处理对先心病患儿心内直视手术的心肌保护作用 被引量:1

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摘要 目的:观察七氟醚预处理对先心病患儿在体外循环下行心内直视手术时的心肌保护作用。方法:选取115例确诊为先天性心脏病的患儿,随机分成对照组和观察组,对患儿常规麻醉成功后,对照组患儿在整个麻醉过程不应用任何吸入麻醉药物;而观察组患儿在主动脉阻断前及开放后分别吸入1.0MAC的七氟醚15min。分别于麻醉成功后(t1)、体外循环结束即刻(t2)、体外循环后2h(t3)、体外循环后5h(t4)、体外循环后8h(t5)测定心肌损伤标志物—心脏型脂肪酸结合蛋白(H-FABP)的血清浓度。结果:各组内t2、t3、t4、t5血清中H-FABP浓度均明显高于t1,有显著性差异(P<0.05);两组间t1点与t2点H-FABP比较,差异无统计学意义(P>0.05);两组间t3、t4、t5点比较差异有统计学差异(P<0.05)。结论:七氟醚预处理可减少行体外循环心内直视手术先心病患儿的心肌缺血再灌注损伤,对患儿心肌有一定的保护作用。
出处 《实用中西医结合临床》 2013年第5期50-51,共2页 Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
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