摘要
糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病常见的微血管并发症之一,是糖尿病微血管病变和神经病变在视网膜微血管环境中的表现,已经成为世界上成年人致盲的主要原因之一。近年来,DR的发病率和致盲率逐年增加,严重影响患者的生存质量。DR的发病机制与多种因素有关,涉及基因多态性、细胞因子、生化机制及炎症作用等,其中VEGF基因多态性成为近年来研究DR发病机制的热点之一。目前发现VEGF基因-634G/C、+405G/C、-2578C/A、936C/T、460C/T等与DR的发生发展具有一定的相关性。但对VEGF基因多态性与DR相关性的研究结果尚无统一的认识。本文就目前DR与VEGF基因多态性的相关研究进展进行综述。
Diabetic retinopathy （DR） is one of the most common microvascular complications of diabetes mellitus. It is manifestation of diabetic microvascular patho- logical change and neuropathy in retinal microvascular environment, and is now one of the main causes of adult blinding in the world. The gradually rising morbidity and blind- ing rate of DR are exerting a serious influence on living quality of patients. DR patho- genesis is associated with many factors, including gene polymorphism, cytokines, bio- chemical mechanism and inflammation, of which polymorphism of VEGF gene has be- come a hotspot of researches for DR pathogenesis in recent years. According to present findings,certain correlations exist between VEGF genes such as -634G/C, ＋ 405G/C, -2578C/A,935C/T,450C/T and DR pathogenesis. Yet there is no common understand- ing about research outcome of correlational study between polymorphism of VEGF gene and DR. This article is to review research advances on correlation between polymor- phism of VEGF gene and DR.
出处
《眼科新进展》
CAS
北大核心
2013年第9期883-886,共4页
Recent Advances in Ophthalmology
基金
国家重点基础研究发展计划(973计划)(编号:2013CB967001)
国家自然科学基金(编号:31271400)
河南省基础与前沿技术研究计划(编号:122300410334)~~
