摘要
目的观察白芍总苷(TGP)联合来氟米特对银屑病关节炎(PsA)血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)的影响,评价其疗效及安全性,并初步探讨其作用机制。方法选取36例确诊PsA患者,接受TGP联合来氟米特方案(治疗组)治疗12周,同时选取20例健康对照组,采用双抗体夹心酶联免疫吸附法(ELISA)分别检测健康对照组、治疗组治疗前、后12周血清TNF-α及IL-8水平。银屑病皮损面积和严重程度指数(PASI)评分为主要疗效指标、健康评定问卷(HAQ)评分为次要疗效指标,并分析治疗前后C反应蛋白(CRP)、红细胞沉降率(ESR)、TNF-α、IL-8水平变化。结果 PsA患者治疗前血清TNF-α、IL-8水平均高于健康对照组,差异均有统计学意义(P<0.05);12周后,治疗组PASI、HAQ、血清TNF-α、IL-8水平均较治疗前改善,差异均具有统计学意义(P<0.01)。治疗12周时,治疗组血清TNF-α、IL-8水平与对照组比较差异无统计学意义(P>0.05)。结论 TGP联合来氟米特治疗PsA具有较好的疗效及安全性,可能通过影响血清TNF-α、IL-8的水平而发挥作用。
Objective To observe the influence of total glucosides of peony（TGP） combined wit.h leflunomide on serum level of TNF-α,IL-8 in the patients with psoriatic arthritis（PsA）, to evaluate its efficacy and safety and to preliminarily study its action mechanism. Methods The open clinical study was adopted. 36 patients with PsA were treated by TGP combined with leflunomide for 12 weeks, at the same time 20 healthy control were selected. The double-antibody sandwich enzyme-linked immunosorbent assay （ELISA） was adopted to detect the level of serum TNF-α and IL-8 before treatment and in 12 weeks after treatmention the two groups. The Psoriasis Area And Severity Index （PASI） was adopted as the main effective index and the Health Assessment Ques- tionaire（HAQ） was taken as the secondary effective index. The level of CRP, ESR,TNF-α, IL-8 before and after treatment were an- alysed. Results The serum TNF-α,IL-8 levels before therapy in the poriatic arthritis group were significantly higher than those in the normal control group（P〈0.05） l after 12 weeks, PASI, HAQ, serum TNF-α and IL-8 levels in the treatment group were signifi- cantly improved than those before treatment, the difference had statistical significance（P〈0.01）, and the serum TNF-α, IL-8 levels were similar to those in the healthy control group without statistical difference（P〉0.05）. Conclusion TGP combined leflunomide for treating PsA has better effect and better safety,which could play the role by influencing serum TNF-α,IL-8 levels.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第26期3131-3133,共3页
Chongqing medicine
关键词
关节炎
牛皮屑
白芍
肿瘤坏死因子-α
白细胞介素-8
arthritis, psoriatic
radix paeoniae alba
tumor necrosis factor-alpha
interleuctkin-8
