摘要
目的探讨水痘合并皮肤及软组织感染的临床特征、细菌学特点以及预后等。方法对本院2007年1月至2010年1月收治的40例水痘合并皮肤及软组织感染病例进行回顾性分析。结果入组患者中,水痘皮肤及软组织感染发生率35.4%(40/113),为住院患者最主要的并发症。溶血性链球菌、金黄色葡萄球菌是水痘患者继发皮肤及软组织感染最常见病原菌。脓毒症休克是死亡的主要原因。本组水痘合并皮肤及软组织感染的患者无一进行水痘免疫接种。存活组和死亡组患者的白细胞(WBC)、血小板(PLT)PLT、丙氨酸氨基转移酶(ALT)、血清白蛋白(ALB)、凝血酶原活动度(PTA)、血肌酐(Cr)、C-反应蛋白(CRP)等指标差异具有统计学意义(P<0.05)。结论水痘合并皮肤及软组织感染者病死率仍较高,积极进行脓毒性休克的预防及治疗尤为关键,接种水痘疫苗可能是从根本上降低并预防水痘并发症的重要举措。
Objective To investigate the clinical features, bacteriology and prognosis of skin and soft tissue infection in varicella cases. Methods Total of 40 cases of varicella combined with skin and soft tissue infection were analyzed from January 2007 to January 2010 in our hospital, retrospectively. Results The incidence of skin and soft tissue infection with varicella inpatient was 35.4% （40/113）, accounting for the primary cause for admission. Group A ^-hemolytic streptococcus （GABHS）, Staphylococcus aureus （SA） were the two major pathogenies. The primary reason of death was septic shock. No patient with skin and soft tissue infection was vaccinated. The white blood cell （WBC）, platele （PLT）, alanine aminotransferase （ALT）, albumin （ALB）, prothrombin time activity （PTA）, creatihine （Cr） and C-reactive protein （CRP） of survival group and death group were all with significant differences （P 〈 0.05）. Conclusions The mortality ofvaricella combined with skin and soft tissue infection is high. It is essential to prevent and administrate septic shock. Varicella vaccination may be an important measure to radically reduce and prevent the complications ofvaricella.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2013年第3期51-54,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
关键词
水痘
皮肤及软组织感染
脓毒性休克
水痘疫苗
Varicella
Skin and soft tissue infection
Septic shock
Varicella vaccine
