摘要
目的神经生长因子对血管性痴呆大鼠治疗作用及可能机制。方法将SD大鼠随机分为三组,假手术组、血管性痴呆组(对照组)、血管性痴呆神经生长因子治疗组(NGF治疗组),2-AO法永久性结扎大鼠双侧颈总动脉制作大鼠血管性痴呆模型,治疗30 d后进行Y型电迷宫检测大鼠学习记忆功能,处死大鼠取脑,测定VEGF及Nestin的表达。结果治疗组大鼠较其他两组大鼠学习记忆能力改善。结论神经生长因子可通过提高血管性痴呆患者血管再生及干细胞增殖改善其认知障碍。
Objective To study the effects of nerve grower factor （NGF） on behavior and the possible mechanism in vascular dementia rats. Methods Sprague dawley rats were divided into sham - operated group, vascular dementia group （ control group ） and vascular dementia of NGF treatment group （ treatment group ）. The model of vascular dementia were established by 2 - AO. The learning and memory ability of the rats were evaluated 30 days after treatment. The rats were killed separately 30 days after operation. The brain sections were used for protein the number of the VEGF and Nestin. Results Learning and memory ability of treatment group improve than those of control group, improve the expression of VEGF and Nestin. Conclu- sion NGF can effectively improve the learning and memory ability by improving the expression of VEGF and Nestin in VD rats.
出处
《药学研究》
CAS
2013年第8期439-441,共3页
Journal of Pharmaceutical Research
