摘要
目的分析糖化血红蛋白对妊娠期糖尿病的诊断价值,探讨其临床适用性。方法选择从2012年1～11月于右江民族医学院附属医院进行产前检查的孕24～28周孕妇,其中的160例妊娠期糖尿病患者作为试验组,另选择同期检查的健康孕妇100例作为对照组,两组均检测空腹血糖、口服糖耐量监测,采用离子交换高效液相色谱分析法检测糖化血红蛋白指标,并用统计学进行相关性分析(ROC曲线),同时分析不同的诊断截断点的灵敏度和特异度。结果妊娠期糖尿病患者与健康孕妇组的空腹血糖进行比较,差异无统计学意义(P>0.05);而餐后血糖及糖化血红蛋白水平显著高于健康孕妇,差异有显著统计学意义(P<0.05);按照ROC曲线分析,曲线下面积(AUC)为0.812,诊断敏感性较高(P<0.05),以糖化血红蛋白5.0%为诊断截断值,糖化血红蛋白诊断妊娠期糖尿病敏感度为81.2%,特异度为84.9%。结论糖化血红蛋白A1c对妊娠期糖尿病有一定的诊断价值,适合临床长期推广应用。
Objective To analyze the diagnostic value of hemoglobin A1c for gestational diabetes.Methods From January to November 2012 pregnant women for prenatal examination in Youjiang Medical College Affiliated Hospital were selected,160 cases with gestation diabetes were chosen as the trial group,and 100 healthy pregnant women of the same period were chosen as the control group.Fasting glucose,oral glucose tolerance testing were done for both groups,ion exchange high performance liquid chromatographic analysis（HPLC） was used to detect HbA1c,the correlation statistical analysis was done（ROC curve）,and sensitivity and specificity of different cutoff values were analyzed.Results Fasting blood glucose of patients with gestational diabetes and healthy pregnant women group was not significantly different（P 0.05）;postprandial blood glucose and glycosylated hemoglobin levels were significantly higher than healthy pregnant women with statistically significantly difference（P 0.05）;according to the ROC curve analysis,the area under the curve（AUC） was 0.812,which is a high diagnosis sensitivity（P 0.05）,HbA1c 5.0% as diagnostic cutoff value,the sensitivity of HbA1c diagnosis of gestational diabetes was 81.2%,and the specificity was 84.9%.Conclusion Hemoglobin A1c have a certain value for the diagnosis of gestational diabetes,which is suitable for long-term clinical application.
出处
《医学综述》
2013年第16期3024-3026,共3页
Medical Recapitulate
关键词
糖化血红蛋白
妊娠期糖尿病
诊断
Glycosylated hemoglobin
Gestational diabetes
Diagnosis
