摘要
神经病理性疼痛是指由躯体感觉神经系统的损伤或疾病而直接造成的疼痛,它不是由直接损伤周围神经所引起,而是由神经系统的异常兴奋(中枢敏化)引起的。其病因和形成机制十分复杂,而通过调节参与突触前神经末梢信号转导及递质释放的离子通道可有效地从源头上减弱痛觉传入,延缓中枢敏化的形成,进而为治疗神经病理性疼痛争取更多的时间。研究表明,突触前钙离子通道、钾离子通道、钠离子通道、氯离子通道、酸敏感离子通道等都参与神经病理性疼痛的形成并各自起着重要作用。
Neuropathic pain is a direct result from injury or disease of the somatosensory nervous system,which is not caused by direct damage to peripheral nerves,but the excited nervous system（central sensitization）.Its etiology and the formation mechanism are very complex,while by adjusting the ion channels involved in presynaptic nerve terminal signal transduction and neurotransmitter release can effectively weaken the nociceptive afferent from the source,delaying the formation of central sensitization,and earn more time for the treatment of neuropathic pain.The studies show that the presynaptic calcium channels,potassium channels,sodium channels,chloride channels,acid-sensitive ion channels and so on are involved in the formation of neuropathic pain,each playing an important role.
出处
《医学综述》
2013年第16期2915-2918,共4页
Medical Recapitulate
