摘要
美罗培南(Meropenem)为第二代碳青霉烯类抗生素,具有非常广泛的抗菌活性,用于治疗多种感染,为一线治疗药物.该文运用一维和二维核磁共振(NMR)波谱对美罗培南及其保护体(protected meropenem)的1H和13C NMR信号进行了全归属和解释,纠正了文献[5]中对美罗培南的C-6和C-7的归属错误,并探讨了美罗培南保护体中由于对硝基苄基的引入使得酰胺键旋转更加困难而产生的旋转异构现象.
Meropenem is a second-generation carbapenems antibiotics with an exceptionally broad spectrum of activity, which is currently used in the treatment of a variety of infections. In this paper, the 1H and 13C NMR chemical shifts of the compound in CDCls and CDaOD （solvents） were assigned. The assignment errors for C-6 and C-7 in the literature were corrected. The C-N bond rotational barrier of protected Meropenem was investigated.
出处
《波谱学杂志》
CAS
CSCD
北大核心
2013年第3期406-416,共11页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金资助项目(21206148)
