摘要
阿尔兹海默病(Alzheimer’s diseases,AD)是一种缓慢发展的神经退行性疾病,其具体发病机制目前并未明确,但出现了很多假说。近来,一种新兴假说引起越来越多的重视,该假说认为AD可能是一种神经内分泌疾病,或者称为"3型糖尿病",因为来自于临床和动物实验的证据表明,AD样病变的脑部显示出胰岛素抵抗的表现。很多研究还发现,大脑中产生的胰岛素及胰岛素样生长因子及与其相关的信号转导通路与AD的进程有着密切的联系。该文就AD进程中的关键因子如β淀粉样蛋白、胆固醇、胰岛素样生长因子等与AD样病变脑部的胰岛素抵抗的关系展开讨论,进一步说明AD与3型糖尿病的关系,为AD分子机制的阐明及治疗提供新的思路。
Alzheimer＇s disease （AD） is a main type of brain neuronal degenerative disease, characterized by neurodegeneration in neocortical regions of the brain. Although pathogenetic mechanisms of Alzheimer＇s disease are not well understood. There are many acceptable hypotheses such as amyloid 13 （A13） theory and cholesterol the- ory. Within the continuously growing body of knowledge in this field, a new hypothesis of AD is emerging which suggestes AD is a nerve endocrine disease or ＂type 3 diabetes＂. Many clinical and animal studies indicate that AD is associated with insulin resistance and insulin and insulin-like growth factor signaling in the brain. In the present review we discussed the relationships between the key factors of AD such as 13 amyloid, cholesterol, insulin-like growth factor, etc. and insulin resistance in the patient＇s brain with AD.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2013年第8期1238-1244,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金面上项目(批准号:31271494)
辽宁省高等学校优秀人才资助计划(批准号:LJQ2011004)资助的课题~~
