摘要
目的:探讨血清胱抑素C(CysC)在造影剂肾损伤早期诊断中的价值。方法:选取300例行冠状动脉造影的患者,术前及术后24、48、72h分别测定血清CysC、血尿素氮、血肌酐和尿微量白蛋白。采用MDRD简化公式计算肾小球滤过率(eGFR)。结果:与术前比较,术后24和48h血清CysC浓度明显升高(P<0.05),术后72h无明显差异;术后24、48及72h的eGFR、血尿素氮、血肌酐、尿微量白蛋白水平变化差异无统计学意义。相关性分析提示,血清CysC与eGFR呈明显负相关性(r=-0.657,P<0.01)。结论:血清CysC是反映造影剂早期肾损伤的有效指标之一。
Objective：To explore the value of serum Cystatin C （CysC） in early evaluation of contrast renal toxicity. Method： A total of 300 patients undergoing coronary angiography were enrolled in this study. Serum CysC, blood urea nitrogen, creatinine,and microalbuminuria were assessed at before angiography, 24 hours, 48 hours, 72 hours after angiography. Glomerular filtration rate was estimated by MDRD. Result.. Serum CysC were significantly higher at 24 hours and 48 hours after angiography （P〈0.05）. The differences of glomerular filtration rate, blood urea nitrogen, creatinine, microalbuminuria between before and after angiography were not significant. Correlation analysis showed that serum CysC was negatively correlated with eGFR. Conclusion.. Serum CysC is an effective biomarker to evaluate early contrast renal toxicity.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2013年第8期588-590,共3页
Journal of Clinical Cardiology
关键词
冠心病
胱抑素C
造影剂
肾损伤
肾小球滤过率
coronary disease
cystatin C
contrast medium
renal injury
glomerular filtration rate
