摘要
【目的】探讨新诊断的2型糖尿病（T2DM）患者血清瘦素、脂联素水平及瘦素／脂联素和颈动脉内膜中层厚度（cIMT）的关系。【方法】以B型超声测定58名新诊断T2DM患者及30名正常对照者的CIMT，以ELISA法测定其血清瘦素、脂联素水平，并计算瘦素／脂联素。【结论】①新诊断的T2DM组血清瘦素水平、瘦素／脂联素、CIMT较正常对照组显著升高而脂联素水平降低（均P〈O．01）；②T2DM组CIMT与年龄、收缩压（SBP）、体质量指数（BMI）、臀围、低密度脂蛋白胆固醇（LDLC）、瘦素、瘦素／脂联素呈显著正相关（P〈O．01，P〈0．05），而与脂联素呈负相关（P〈0．01）。③在新诊断的T2DM组，瘦素、脂联素、瘦素／脂联素与cIMT独立相关（P〈0．05）。【结论】瘦素／脂联素可能是预测T2DM患者早期动脉粥样硬化程度更好的指标。
[Objective]To explore the relationship of carotid intim^media thickness（CIMT） with serum levels of leptin and adiponectin and the ratio of leptin to adiponectin in newly diagnosed type 2 diabetic（TSDM） patients. [Methods] CIMT of 58 newly diagnosed T2DM patients and 30 normal controls was measured by B-type ultrasound. ELISA was used to detect serum levels of leptin and adiponectin. The ratio of leptin to adiponectin was calculated. [Results] Compared with normal control group, serum level of leptin, the ratio of leptin to adiponectin and CIMT in newly diagnosed T2DM group were significantly increased（ P d0.05, P d0.01 and P d0.01, respectively）, but se rum level of adiponectin was decreased（ P d0.01）. CIMT in T2DM group was positively correlated with age, systol- ic blood pressure （SBP）, body mass index（BMI）, hip circumference, low density lipoprotein-cholesterol （LDL-C）, leptin and the ratio of leptin to adiponectin significantly（ P d0.01, P d0.05）, but negatively correlated with adi- ponectin. In newly diagnosed TSDM group, CIMT was independently correlated with leptin, adiponectin and the ratio of leptin to adiponectin（ P d0.05）. [Conclusion]The ratio of leptin to adiponectin may be a better clinical marker of predicting the early atherosclerosis in T2DM patients.
出处
《医学临床研究》
CAS
2013年第8期1518-1521,共4页
Journal of Clinical Research
关键词
糖尿病
2型
血液
瘦素
A液
脂联素
A液
颈动脉
Diabetes Mellitus, Type 2/BL
Leptin/BL
Adiponectin/BL
Carotid Arteries
