摘要
目的探讨血管危险因素与前、后循环颅内动脉狭窄之间的关系。方法对374例急性脑梗死患者进行磁共振血管成像检查,按颅内动脉狭窄的部位分两组(前、后循环颅内动脉狭窄组),对可能影响前、后循环颅内动脉狭窄的危险因素进行分析比较。结果单因素分析发现前、后循环颅内动脉狭窄在收缩压、吸烟史、饮酒史、卒中史、出院时国立卫生研究院卒中量表(NIHSS)评分、短期预后、血肌酐、血甘油三酯、低密度脂蛋白胆固醇(LDL-c)问差异均有统计学意义(P均〈0.05)。多因素Logistic回归分析显示,前循环颅内动脉狭窄与高血糖(OR=1.135,95%CI:1.003~1.284)、卒中史(OR=1.133,95%CI:1.007—1.276)、短期预后(OR=5.987,95%CI:1.441~24.873)有关,后循环颅内动脉狭窄与吸烟史(OR=0.003,95%CI:0.000~0.376)、血肌酐(OR=0.509,95%CI:0.328~0.790)、高甘油三酯(OR=0.054,95%CI:0.004—0.645)、高LDL—C(OR=0.096,95%CI:0.015~0.608)有关。结论血管性危险因素对前、后循环颅内动脉狭窄所施加的效应是不同的。
Objective To investigate the association between vascular risk factors and the location of intracranial artery stenosis (anterior versus posterior). Methods Magnetic resonance angiography(MRA) were examined in 374 acute stroke patients. It was divided into two groups (anterior and posterior intracranial artery stenosis group). Analyzed possible risk factors. Results Univariate analysis showed there were differences between anterior and posterior intracranial artery stenosis in systolic blood pressure, history of smoking, drinking and stroke status, and national institutes of health stroke scale (NIHSS) score at discharge, short-term prognosis, serum creatinine, triglyceride, low density lipoprotein cholesterol ( LDL-C ) ( P 〈 0. 05 ) . In multivariate logistic regression analysis, high blood sugar ( OR = 1. 135,95% CI: 1. 003 - 1. 284 ), history of stroke( OR = 1. 133,95% CI: 1. 007 - 1. 276 ), good short-term prognosis ( OR = 5. 987,95% CI: 1. 441 - 24. 873 ) were preferentially related to anterior intracranial artery stenosis, whereas history of smoking ( OR = 0. 003,95% CI:0. 000 - 0. 376 ), high serum creatinine values ( OR = 0. 509,95% CI: O. 328 - 0. 790 ), high triglyeeride values ( OR = 0. 054,95% CI: 0. 004 - 0. 645 ) and high LDL-C values ( OR = 0. 096,95% CI: 0. 015 -0. 608) were preferentially related to posterior intracranial artery stenosis. Conclusion Vascular risk factors appeared to exert different effects of risk for anterior and posterior intracranial artery stenosis.
出处
《中国综合临床》
2013年第9期897-900,共4页
Clinical Medicine of China
基金
河北省医学科学研究重点课题(20120238)
关键词
缺血性卒中
前循环颅内动脉狭窄
后循环颅内动脉狭窄
危险因素
Ischemic stroke
Anterior intracranial artery stenosis
Posterior intracranial arterystenosis
Risk factors