摘要
目的探讨活血化瘀通络治疗慢性肾衰竭(CRF)患者血清脂联素(ADPN)水平的变化与临床的关系。方法选取52例CRF患者随机分为治疗组和对照组,每组26例,两组均用常规AXTR治疗方案,治疗组加用活血化瘀通络治疗3个月,于治疗前后分别检测患者血清ADPN、白细胞介素-10(IL-10)和肿瘤坏死因子-α(TNF-α)水平,并与20例健康体检者(健康组)比较。结果治疗组治疗前血清ADPN、IL-10和TNF-α水平为(23.43±8.63)g/L、(47.41±23.28)pg/ml和(39.14±17.35)pg/ml,治疗后为(7.87±5.85)mg/L、(8.76±5.63)pg/ml和(9.74±7.35)pg/ml。治疗前高于健康组(P<0.01),治疗后差异无统计学意义(P>0.05);对照组治疗前血清ADPN、IL-10和TNF-α平均水平为(22.98±7.71)mg/L、(37.52±21.45)pg/ml和(38.82±16.75)pg/ml,治疗后为(17.98±9.63)mg/L、(27.33±7.41)pg/ml和(22.76±12.42)pg/ml,治疗前高于健康组(P<0.01),治疗后血清ADPN、IL-10和TNF-α平均水平虽有下降,但仍高于健康组(P<0.01)。结论活血化瘀通络可有效改善CRF患者的炎症损害机能,减缓病情进展。
Objective To observe the changes of the serum adiponectin （ADPN）level in CRF （chronic renal failure） patients who were treated by Huoxue Huayu Tongluo Therapy （the Chinese herb therapy for activating blood circulation to dissipate blood stasis）. Methods 52 cases of CRF patients were randomly divided into the treatment group and the control group with 26 cases in each group. Conventional AXTR treatment were used in both groups for 3 months, but the treatment group was added Huoxue Huayu Tongluo Therapy. The serum ADPN, interleukin ]0 （IL-10） and tumor necrosis factor alpha（TNF- a） levels of these patients were detected before and after the treatment and then were compared with those of the 20 healthy people（the healthy group）. Results The serum ADPN, interleukin-10 （IL-10） and tumor necrosis factor alpha （TNF-α） levels of the treatment group before treatment were （23.43±8.63） mg/L,（47.41±23.28） pg/ml and （39.14±17.35） pg/ml respectively,which were significantly high- er than those of the healthy group（ P 〈0.01）. But after the treatment they were （7.87-^-5.85） mg/L, （8.76--I-5.63） pg/ml and （9.74±7.35）pg/ml respectively, which were not statistically diffrent from those of the healthy group（ P 〈0.05）. The mean levels of the serum ADPN,interleukin-10 （IL-10） and tumor necrosis factor alpha （TNF-α） of the control group were（22.98±7.71） mg/L, （37.52±21.45） pg/ml and （38.82±16.75） pg/ml before treatment,and they decreased to （17.98 ±9.63） mg/L, （27.33 ±7.41） pg/ml and （22.76 ±12.42） pg/ml, respectively, after the treatment. Thus they were still higher than those of the healthy group（ P 〈0.01）. Conclusion The Chinese Huoxue Huayu Tongluo therapy can effectively alleviate the inflammatory damage in patients with CRF function and slow down the progression.
出处
《右江医学》
2013年第4期487-489,共3页
Chinese Youjiang Medical Journal
基金
2011年广西壮族自治区教育厅基金资助项目(合同编号:201010LX377)
广西壮族自治区卫生厅基金资助项目(合同编号:Z2009266)
关键词
慢性肾衰竭
炎症因子
中药治疗
chronic renal failure
inflammatory factor
Chinese herb therapy
