摘要
目的观察序贯疗法对于青少年颜面部痤疮的疗效及不良反应。方法选择2010年1月至2012年12月期间前来我院皮肤科门诊就诊的颜面部痤疮患者共274例,按随机数字表随机分配成治疗组137例和对照组137例。治疗组给予强力霉素每天0.2g,分两次服用连续给药2周后,停止服用强力霉素同时改服异维A酸胶丸每天20 mg,分两次服用,连续给药10周;对照组仅给予异维A酸胶丸每天20 mg,分两次服用,连续给药12周。治疗结束后对比两组的疗效和不良反应。结果两组研究对象在完成全部治疗后就治疗效果进行对比,其中治疗组痊愈34例,显效71例,有效26例,无效6例,总有效率76.6%;对照组痊愈27例,显效53例,有效46例,无效11例,总有效率58.4%;组间比较其差异有统计学意义(χ2=10.401,P<0.01)。结论青少年颜面部痤疮运用序贯疗法具有疗效确切,不良反应少的优点,可以在临床上推广运用。
Objective Observation of sequential therapy for the curative effect and adverse reaction of facial ache in adolescents. Methods We chose 274 cases with facial acne in 2010 January -2012 December visited clinic of dermatology in our hospital. All cases were randomly divided into treatment group （137 cases） and control group （137 cases）. The treatment group was given doxycycline 0.1g bid for 2 weeks, after that given isotretinoin 10 mg bid for 10 weeks; the control group was only given isotretinoin 10 mg bid for 12 weeks. When the treatment were finished, compared between the two groups in treatment efficacy and adverse reaction. Results In the treatment group 34 cases were cured, 71 cases were markedly effect, 26 cases were effect, 6 cases were no effect, the total efficiency were 76.6%; in the control group 27 cases were cured, 53 cases were markedly effect, 46 cases were effect, 11 cases were no effect, the total efficiency were 58.4%. There are statistically significant differences between the two groups （x^2=10.401, P〈0.01）. Conclusion The sequential therapy in the treatment of facial acne in adolescents has curative effect and fewer side effects, that can be popularized in clinical application.
出处
《中国医药指南》
2013年第18期468-469,共2页
Guide of China Medicine
关键词
青少年
痤疮
序贯疗法
异维A酸
强力霉素
Adolescents
Acne
Sequential therapy
Isotretinoin
Doxycycline
