摘要
目的:探讨冠心病(CHD)患者血浆超敏C反应蛋白(Hs-CRP)、同型半胱氨酸(HCY)水平与脉搏波传导速度(PWV)之间的关系。方法:经冠状动脉造影确诊的57例CHD患者(CHD组),根据冠状动脉病变支数分为单支病变亚组14例、双支病变亚组26例和多支病变亚组17例;另选25名健康体检者作为对照组。分别检测入选人群的血浆Hs-CRP、HCY水平及PWV;同时检测各组空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。结果:与对照组比较,CHD组血浆FPG、TG、TC、LDL-C、Hs-CRP、HCY水平和PWV均明显升高(P<0.01)。CHD组各亚组间比较,血浆Hs-CRP、HCY水平和PWV随冠状动脉病变支数的增加而升高,各亚组间差异有统计学意义(P<0.05～P<0.01)。CHD组Hs-CRP、HCY水平升高与PWV升高均呈正相关关系(P<0.05)。结论:血浆Hs-CRP、HCY水平和PWV在CHD患者中明显升高,并与冠状动脉病变程度密切相关,可用于预测动脉粥样硬化的严重程度。
Objective： To observe the correlation between the plasma level of high sensitivity C creactive protein （Hs-CRP）, homocysteine（HCY） and pulse wave velocity （PWV） in patients with coronary heart disease （CHD）. Methods： Fifty-seven CHD patients confirmed by coronary angioplasty were divided into single-vessel-lesion group （14 cases）, double-vessel-lesion group （26 cases） and triple-vessel-lesion group （17 cases）, while 25 healthy adults were selected as control. The Hs-CRP, HCY, plasma glucose（FPG）, triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol（ HDL-C ） and PWV were detected in each group. Results：Compared with the control, the plasma level of FPG, TG,TC, LDL- C,Hs-CRP,HCY and PWV of the CAD group increased significantly （P 〈 0.01 ）. The plasma level of Hs-CRP, HCY and PWV increased in accordance with the number of the coronary lesion （ P 〈 0.05 to P 〈 0.01 ）. The plasma level of HCY was positively correlated with that of Hs-CRP, HCY and PWV （ P 〈 0.05 ）. Conclusions ： The plasma level of Hs-CRP, HCY and PWV are high in patients with CHD and closely correlated with the degree of the coronary lesion,which may be of use in predicting the severity of the CHD.
出处
《蚌埠医学院学报》
CAS
2013年第6期700-702,共3页
Journal of Bengbu Medical College
