摘要
目的:考察盐酸曲马多注射液与氟哌利多注射液在0.9%氯化钠注射液中的配伍稳定性。方法:在室温条件下,采用高效液相色谱法(HPLC)测定配伍液72 h内盐酸曲马多与氟哌利多的含量变化,并观察和检测配伍液的外观、不溶性微粒及pH变化。结果:配伍液在72 h内盐酸曲马多与氟哌利多含量、不溶性微粒、外观及pH均无明显变化。结论:盐酸曲马多注射液与氟哌利多注射液在0.9%氯化钠注射液中,室温条件下72 h内保持稳定。
Objective：To study the stability of the mixture of tramadol hydrochloride injections and droperidol injections in 0.9% sodium chloride injections.Method：An HPLC method was used to study the content change after the combination of tramadol hydrochloride with droperidol in 0.9%sodium chloride injections at ambient temperature in 72 h,the appearance was observed,and the pH value and insoluble particles were determined.Result：In 72h alter the combination,no obvious change in the observation indices was found.Conclusion-.The mixture of tramadol hydrochloride and droperidol in 0.9%sodium chloride injections is stable in 72 h at room temperature.
出处
《中国药师》
CAS
2013年第8期1177-1179,共3页
China Pharmacist
