摘要
目的研究急性和慢性腹泻患者与正常人的肠道菌群变化差异。方法对慢性腹泻组22例、急性腹泻组35例,对照组20例的成年患者粪便进行肠杆菌、肠球菌、双歧杆菌、乳酸杆菌检测分析与比较。结果急性腹泻患者与对照组相比肠杆菌显著增加,而双歧杆菌、乳酸杆菌、类杆菌及肠球菌显著减少(P<0.01),慢性腹泻患者的肠杆菌明显增加,乳酸杆菌明显减少(P<0.05),双歧杆菌、类杆菌及肠球菌较对照组减少,但结果差异无统计学意义。急性腹泻者厌氧菌较慢性腹泻者有所减少,其中类杆菌和乳杆菌显著减少(P<0.05)。结论无论急慢性腹泻患者都存在肠道菌群失调的情况,其中急性腹泻患者更加明显。
Objective To investigate the changes in the intestinal flora of patients with acute and chronic diarrhea. Methods With 22 patients as the chronic diarrhea group, 35 patients as the acute diarrhea group and 20 healthy adults as the control group, the faecel specimens of all three groups were detected for Enterobacilli, Enterococci, Bifidobactenia, Lactobacilli and Bacteroides ; the results were analyzed and compared. Results The colony forming units of Enterobacterium of acute diarrhea group increased and those of Enterococ- cus, Bifidobacterum, LactobaciUum and Bacteroides decreased, comparing with the control group （P 〈 0.01 ） ; the units of Enterobacterium increased and that of Lactobacillum decreased in patients with chronic diarrhea （P 〈 0.05 ）. Moreover, the numbers of Bateroides and Lactobacillum in patients with chronic diarrhea decreased less significantly than that in patients with acute patients （ P 〈 0. 05 ）. Conclusion Both patients with acute and chronic diarrhea have intestinal dysbacteriosis, and the intestinal flora in patients with acute di- arrhea was disturbed more severely than those with chronic diarrhea.
出处
《中国微生态学杂志》
CAS
CSCD
2013年第8期960-961,共2页
Chinese Journal of Microecology
关键词
腹泻
肠道菌群
菌群失调
Diarrhea
Intestinal tract microflora
Dysbiosis
