摘要
目的观察加味六君子汤治疗功能性消化不良伴抑郁症患者的临床疗效。方法将80例功能性消化不良伴抑郁症患者随机分为治疗组和对照组各40例,对照组给予多潘立酮片10mg,每日3次;圣约翰草提取物片300mg,每日3次。治疗组在对照组基础上给予加味六君子汤,每日1剂。两组均治疗30天后评价中医证候疗效,于治疗前后采用17项汉密尔顿量表(HAMD-17)评价抑郁程度,并检测胃动素(MOT)及促胃泌素(GAS)及胃排空率。结果两组中医证候疗效比较,治疗组总有效率(95.0%)明显高于对照组(87.5%),差异有统计学意义(P<0.05)。治疗组HAMD-17积分改善、MOT、GAS及胃排空率均明显优于对照组,差异有统计学意义(P<0.05)。结论加味六君子汤能够显著改善功能性消化不良伴抑郁症患者的临床症状,升高MOT、GAS水平及胃排空率。
Objective To observe the therapeutic effect of Modified Liujunzi Decoction for functional dyspepsia with depression. Methods Eighty cases of functional dyspepsia with depression were randomized into the treatment group and control group, with 40 in each. The control group was given domperidone tablets 10rag each time, 3 times daily and St. John ＂s wort extract tablets 300rag each time, 3 times daily. The treatment group was added with Modified Liujunzi Decoction one dose daily. Both groups were treated for 30 days. The total efficacy and the degrees of depression were evaluated. The motilin （MOT） and gastrin （GAS） was detected and the gastric emptying test was conducted. Results The total effective rate of TCM patterns in the treatment group and control group was 95. 0% and 87. 5% respectively, with a significant difference between groups （P〈0. 05）. Comparing with the control group, the scores of Hamilton Depression Rating Scale, the levels of MOT and GAS and the results of gastric emptying test in the treatment group were significantly improved （P 〈 0.05）. Conclusion Modified Liujunzi Decoction can obviously relieve the symptoms of functional dyspepsia patients with depression. It can increase the levels of MOT and GAS and gastric emptying rate.
出处
《中医杂志》
CSCD
北大核心
2013年第17期1480-1482,共3页
Journal of Traditional Chinese Medicine
关键词
功能性消化不良
抑郁症
加味六君子汤
functional dyspepsia
depression
Modified Liujunzi Decoction
gastric emptying test
