摘要
目的探讨止血药对膀胱肿瘤患者术后凝血状态的影响。方法选择进行住院治疗的膀胱肿瘤患者82例，按随机数字表法分为观察组和对照组，每组41例。观察组患者应用止血药，对照组患者不使用止血药。比较两组患者术后的凝血状态。结果两组患者术前凝血指标比较差异无统计学意义（P〉0．05）；与术前比较，观察组和对照组患者术后1、2d的APTT和PT延长，PAI-1、t-PA、D—D显著增高，PLT减少，1Tr缩短，差异均有统计学意义（P〈0．05）；术后1、2d比较，观察组患者的TT短于对照组[（14．36±0．17）s比（15．42±0．18）s和（14．36±0．28）s比（15．29±0．27）s]，PAI-1、t-PA、D．D显著高于对照组[（98．19±2．32）ng／L比（82．19±2．38）μg／L和（84．52±2．25）μg/L比（72．94±2．26）μg/L，（27．06±1．69）μg/L比（21.63±1．16）μg/L和（27．28±1．37）μg/L，L比（21．69±1．19）μg/L，（7．06±0．08）μg/L，L比（1．89±0．28）μg/L和（12．83±1．05）μg/L，L比（1．96±0．18）μg/L，差异均有统计学意义（P〈0．05），两组PLT、APTT、PT比较差异均无统计学意义（P〉0．05）；观察组患者下肢深静脉血栓形成发生率为7．32％（3／41），对照组为2．4.4％（1／41），两组比较差异无统计学意义（P〉0．05）。结论应用止血药可以加重膀胱肿瘤患者术后的高凝状态。因此，应慎重应用预防性止血药。
Objective To investigate the effect of hemostatic drug on coagulation status after operation of bladder tumor. Methods Eighty-two bladder tumor patients in hospital for treatment were selected,and were randomly divided into observation group and control group with 41 patients in each. The patients in observation group were treated with hemostatic drug after operation, and the patients in control group were treated without hemostatic drug. The coagulation status between two groups were compared after operation. Results The index of preoperative coagulation status between two groups had no significant difference （P 〉 0.05 ）. Compared with the preoperative, the activated partial thromboplastin time （APTT） and prothrombin time （PT） in two groups were prolonged on postoperative 1,2 d, plasminogen activator inhibitor （PAI）-1, tissue plasminogen activator （t-PA）,D-Dimer （D-D） were increased,platelet （PLT） was decreased, thrombin time （TY） was shortened, there were significant differences （P 〈 0.05 ）. On postoperative 1,2 d, TY in observation group was shorter than that in control group[ （ 14.36 ＋ 0.17） s vs. （ 15.42± 0.18） s, （14.36 ± 0.28 ） s vs. （15.29± 0.27 ） s ], PAI-1 ,t-PA, D-D were significantly higher than those in control group [（98.19±2.32） μg/L vs. （82.19±2.38）μg/L,（84.52±2.25）μg/L vs. （72.94±2.26） μg/L, （27.06 ± 1.69） μg/L vs.（21.63 ±1.16） μg/L, （27.28 ±1.37）μg/L vs. （21.69 ± 1.19） μg/L, （7.06 ±0.08 ） μg/L vs. （ 1.89±0.28 ） μg/L, （ 12.83± 1.05 ） μg/L vs. （ 1.96 ± 0.18 ） μg/L ], there were significant differences （P 〈 0.05 ）. No significant difference was found in PLT, AFFr, PT between two groups （P 〉 0.05 ）. The incidence of deep vein thrombosis （DVT） in observation group and control group was 7.32% （3/41）, 2.44% （ 1/41 ）, which had no significant difference （P 〉 0.05 ）. Conclusions The application of hemostatic drug can aggravate hypercoagulabilit
出处
《中国医师进修杂志》
2013年第23期30-32,共3页
Chinese Journal of Postgraduates of Medicine
关键词
止血药
膀胱肿瘤
凝血状态
Hemostatie drug
Bladder tumor
Coagulation status
