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DAB2IP基因与肿瘤 被引量：4

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摘要 DAB2IP是新发现的抑癌基因，是Ras—GTP酶激活蛋白家族的新成员。它通过介导多种肿瘤相关信号通路，如MAPK—ERK，P13K-Akt，ASK1-JNK和GSK-3B—B—catenin等，影响细胞的增殖、存活和凋亡。研究发现DAB2IP在多种肿瘤中表达下调，包括前列腺癌、乳腺癌、肺癌、胃肠肿瘤、肝细胞癌以及成神经管细胞瘤等，并且与肿瘤的进展及预后密切相关。本文拟对当前关于DAB2IP与肿瘤相关性的研究文献进行汇总综述，讨论DAB2IP作为分子标志物判断肿瘤恶性进展以及治疗预后的可行性。
作者 章婷婷 孔肇路
机构地区 复旦大学放射医学研究所
出处 《标记免疫分析与临床》 CAS 2013年第4期277-280,共4页 Labeled Immunoassays and Clinical Medicine
关键词 DAB2IP基因 肿瘤 分子标志物
分类号 R730.2 [医药卫生—肿瘤]
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参考文献25

  • 1Chen H, Pong R, Wang Z,et al. Differential regulation of thehuman gene DAB2IP in normal and malignant prostatic epithelia :Cloning and characterization [ J ]. Genomics,2002,79 ( 4 ):573-581. 被引量：1
  • 2Mok S C, Wong K K, Chan R K, et al. Molecular- cloning of differentielly expressed genes in numan epithelial ovarian-cancer [ J ]. Gynecol Oncol, 1994, 52(2) : 247-252. 被引量：1
  • 3Chen H,Toyooka S,Gazdar A, et al. Epigenetic regulation of anovel tumor suppressor gene ( hDAB2IP) in prostate cancer celllines[J]. J Biol Chem, 2003, 278(5) : 3121-3130. 被引量：1
  • 4Chen H, Tu S, Hsieh J. Down-regulation of human DAB2IP geneexpression mediated by polycomb Ezh2 complex and histone deacety-lase in prostate cancer [ J ]. J Biol Chem, 2005,280 (23):22437-22444. 被引量：1
  • 5Min J, Zaslavsky A, Fedele G, et al. An oncogene-tumor suppres-sor cascade drives metastatic prostate cancer by coordinately activa-ting Ras and nuclear factor-kappa B[ J]. Nat Med, 2010, 16(3):286-294. 被引量：1
  • 6Xie D,Gore C,Zhou J, et al. DAB2IP coordinates both PI3K-Aktand ASK1 pathways for cell survival and apoptosis[ J]. Proc NatlAcad Sci USA, 2009, 106(47) : 19878-19883. 被引量：1
  • 7Zhang H,Zhang R, Luo Y, et al. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation[ J]. J Biol Chem, 2004, 279 (43) : 44955-44965. 被引量：1
  • 8Zhang R, He X,Liu W, et al. AIP1 mediates TNF-alpha-inducedASK1 activation by facilitating dissociation of ASK1 from its inhibitor14-3-3[J]. J Clin Invest, 2003,111(12) : 1933-1943. 被引量：1
  • 9Liu Y, Yin G, Surapisitchat J, et al. Laminar flow inhibits TNF- induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3[J]. J Clin Invest, 2001, 107(7) : 917-923. 被引量：1
  • 10Zhang L, Chen J, Fu H. Suppression of apoptosis signal-regulatingkinase 1 - induced cell death by 14-3-3 proteins[ J]. Proc Natl AcadSci USA, 1999,96(15) : 8511-8515. 被引量：1

同被引文献36

  • 1沈益君,叶定伟.浸润性膀胱癌保留膀胱的综合治疗进展[J].中国癌症杂志,2007,17(3):265-268. 被引量：7
  • 2Chen H, Pong R, Wang Z, et al. Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: Cloning and characterization [J]. Genomics, 2002, 79(4): 573-581. 被引量：1
  • 3Min J, Zaslavsky A, Fedele G, et al. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappa B [J] Nature Medicine, 2010, 16(3): 286-294. 被引量：1
  • 4Xie D, Gore C, Zhou J, et al. DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis [J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(47): 19878-19883. 被引量：1
  • 5Zhang H, Zhang R, Luo Y, et al. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation [J]. Journal of Biological Chemistry, 2004, 279(43): 44955-11965. 被引量：1
  • 6Zhang R, He X, Liu W, et al. AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 [J]. Journal of Clinical Investigation, 2003, 111(12): 1933-1943. 被引量：1
  • 7Liu Y, Yin G, Surapisitchat J, et al. Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3 [J]. Journal of Clinical Investigation, 2001, 107(7): 917-923. 被引量：1
  • 8Zhang L, Chen J, Fu H. Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins [J]. Proceedings of the National Academy of Sciences of the United States of America, 1999, 96(15): 8511-8515. 被引量：1
  • 9Kong Z, Xie D, Boike T, et al. Downregulation of Human DAB2IP Gene Expression in Prostate Cancer Cells Results in Resistance to Ionizing Radiation [J]. Cancer Research, 2010, 70(7): 2829-2839. 被引量：1
  • 10Jacobs C, Tumati V, Kapur P, et al. DOC-2/DAB2 interacting protein status in high-risk prostate cancer correlates with outcome for patients treated with radiation therapy [J]. International Journal of Radiation Oncology·Biology·Physics, 2014, 89(4): 729-735. 被引量：1

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标记免疫分析与临床
2013年 第4期

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