摘要
目的探讨小牛血清去蛋白提取物对放射性肠炎的防治作用,寻找能够有效防治各种放射性黏膜损伤的理想药物。方法将Ⅱ、Ⅲ期盆腔肿瘤患者108例随机分成观察组和对照组各54例,观察组行放疗+小牛血清去蛋白提取物保留灌肠,对照组行放疗+地塞米松等药物保留灌肠,观察两组相关血清和临床指标在治疗前后的变化。结果在疗程内,随着时间的推移,C反应蛋白(CRP)的水平不断升高,观察组的CRP增长速度慢于对照组(P<0.05);与对照组相比,观察组能显著延长首次直肠临床症状的发生时间;放疗结束后,观察组总有效率为81.48%,显著高于对照组的59.26%,差异具有统计学意义(P<0.05)。结论小牛血清去蛋白提取物可有效调节CRP水平,减轻放疗所致的直肠黏膜免疫损伤,推迟直肠黏膜炎症的发生时间。
Objective To investigate the prevention and treatment of radiation-induced enteritis by protein-free hemodialysate. Methods 108 patients with [[ and IlI pelvic tumors were randomly divided into observation group （n=54） and control group （n=54）.Patients in observation group received radiotherapy combined with protein-free hemodialysate atomization inspiration,while patients in control group received radiotherapy combined with dexamethasone.Symptoms related to radiation enteritis and serum indexs were observed before and after treatments. Results The levels of C reactive protein （CRP） were increased with the treatment process,CRP growth of observation group was slower than that of control group （P 〈 0.05）;the time of occurrence of the first clinical symptoms of rectum of observation group were significantly longer than that of control group （P 〈 0.05）; after the end of radiotherapy,the total effective rate of was 81.48% in observation group were significantly higher than that of 59.26% in control group （P 〈 0.05）. Conclusion Protein-free hemodialysate can effectively regulate the level of CRP,rectal mncosal immune injury caused by radiotherapy,and delay time of rectal mucosal inflammation.
出处
《中国医药科学》
2013年第16期15-17,共3页
China Medicine And Pharmacy
