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索拉非尼单药治疗FLT3-ITD突变阳性急性髓系白血病一例 被引量:4

Sorafenib monotherapy for FLT3-ITD positive acute myeloid leukemia: a case report
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摘要 患者,男,63岁。主因发热、咳嗽及皮下出血1周于2012年7月26日收住我院。外院查血常规提示白细胞增高、贫血,后多次复查血常规提示白细胞进行性增高。入院时查体:体温37.0℃,贫血貌,皮肤黏膜可见散在瘀点、瘀斑,全身浅表淋巴结无肿大,胸骨无压痛,余未见明显异常。
出处 《中华血液学杂志》 CAS CSCD 北大核心 2013年第8期736-736,共1页 Chinese Journal of Hematology
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同被引文献21

  • 1王莉红,周春林,张新伟,陈森,王敏,王建祥.FLT3基因内部串联重复突变与急性白血病的关系及临床意义[J].中华血液学杂志,2004,25(7):393-396. 被引量:35
  • 2Kusec R, Jaksic O, Ostojic S, et al. More on prognostic significance of FLT3-ITD size in acute myeloid leukemia ( AML ) [ J ]. Blood, 2006, 108 ( 1 ) : 405- 406. 被引量:1
  • 3Kuchenbauer F, Kern W, Schoch C, et el. Detailed analysis of expression levels in acute myeloid leukemia [ J ]. Haema tologica, 2005, 90 ( 12 ) : 1617- 1625. 被引量:1
  • 4Wang L, Lin D, Zhang X, et al. Analysis of FLT3 internal tandem duplication and D835 mutations in Chinese acute leukemia patients [ J ]. Leuk Res, 2005, 29 ( 12 ) : 1393-1398. 被引量:1
  • 5Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics. FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease [ J ]. Blood, 2002, 100 ( 1 ) : 59-66. 被引量:1
  • 6Haferlach T, Schoch C, Schnittger S, et al. Distinct genetic patterns can be identified in acute monoblastic and acute monocytic leukaemia (FABAMLM5aandM5b): a study of124 patients [J]. BrJ Haematol, 2002, 118 ( 2 ) : 426-431. 被引量:1
  • 7A1-Mawali A, Gillis D, Lewis I. Characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplication in the FLT3 gene[ J ]. Oman Med J, 2013, 28(6) : 432-440. 被引量:1
  • 8Rombouts WJ, Blokland I, Lwenberg B, et al. Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene [ J ]. Leukemia, 2000, ld ( 4 ) : 675-683. 被引量:1
  • 9Yang Z, Tian H, Xu Y, et al. Clinical outcome of FLT3-ITD ( + ) acute myeloid leukemia patients treated with allogeneic hematopoietic stem cell transplantation [ J ]. Zhonghua Nei Ke Za Zhi, 2014, 53 ( 2 ) : 94-98. 被引量:1
  • 10Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia[ J ]. Blood, 2002, 100( 5 ) : 1532-1542. 被引量:1

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