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替比夫定治疗慢性乙型肝炎患者血清人类白细胞抗原I及肿瘤坏死因子相关性凋亡诱导配体的变化 被引量:1

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摘要 HBV感染的机制复杂,其中机体免疫清除病毒的能力发挥极为重要的作用,既能够控制病毒的复制和清除、促进病情恢复和使机体产生保护性的免疫应答,也会导致炎性损伤迁延不愈。可溶性人类白细胞抗原工(sHLA-工)类分子是肝细胞破坏时的释放物,除反映肝细胞损伤外,还是一种重要的免疫调节物质.可溶性肿瘤坏死因子相关性凋亡诱导配体(sTRAIL)对正常生理状态下的机体组织没有毒性,病理状态下被激活参与机体的免疫反应,被认为是机体的一个典型的免疫监视分子。本研究通过测定慢性乙型肝炎(CHB)患者在应用替比夫定治疗过程中血清sHLA-工类分子及sTRAII。的含量,分析以上细胞因子的变化特点及意义。
出处 《中华传染病杂志》 CAS CSCD 北大核心 2013年第7期427-429,共3页 Chinese Journal of Infectious Diseases
基金 宁夏自然科学基金资助项目(NZ10118)
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