摘要
目的前瞻性对比腹腔镜与开腹胃癌根治术后机体应激细胞炎性因子的变化,分析两种手术方式对机体应激反应的影响。方法选取60例需行胃癌根治术的胃癌患者为研究对象,随机分为腹腔镜组与开腹组各30例,腹腔镜组采用腹腔镜胃癌切除术,开腹组实施开腹手术,分别于术前、术中(D0)、术后第1天(D1)、第3天(D3)、第5天(D5)测定患者各应激指标[一氧化氮(NO)、内皮素(ET)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]的变化及组间的差异。结果分析两组内部各应激指标计数的变化及组间相应应激指标的组间差异,两组患者各应激指标有一种趋势,术后即开始升高,术后达到高峰后开始下降,逐渐恢复至术前水平,并且腹腔镜组NO、ET、IL-6和CRP水平显著低于开腹组(P<0.05)。结论腹腔镜组患者炎症应激反应程度低于开腹组,腹腔镜胃癌根治术较开放手术对机体创伤小,应激反应小。
Objective To explore the influence of laparoscopic-assisted and open radical gastrectomy for gastric cancer on systemic stress response.Methods The clinical data of 60 gastric cancer patients between June 2011 and January 2013 were analyzed.These patients were divided into laparoscopic and open group.Laparoscopic group is laparoscopic-assisted group and the open group is open radical gastrectomy.Then we determined the stress indexes of patients before and after the operation,and compared the data of two groups.Results By comparing the data of two groups,we can get the result that the stress indexes of both groups have a tendency.The tendency is that all indexes of all these patients went up after the operation,got peak,then,went down to the level of preoperative.The mean stress indexes of laparoscopic-assisted group was significantly less than that of open radical gastrectomy group（P 0.05）.Conclusion Laparoscopic-assisted group has less effect on systemic stress response than open operation.Therefore,laparoscopic-assisted group has less damage on body than open operation.
出处
《临床和实验医学杂志》
2013年第14期1113-1115,1117,共4页
Journal of Clinical and Experimental Medicine
基金
首都医学发展基金支持项目(No.2009-2060)
