摘要
本文研究海马内NA能神经损毁对艾灸抗炎免疫作用的影响 ,探讨其中枢调节机理。实验建立AA大鼠模型 ,应用 6 OHDA作海马内微量注射 ,观察灸疗对跖围、胸和脾指数、IL 6、IL 2等炎症和免疫指标的改变。实验表明 ,艾灸组有显著的抗炎免疫作用 ,与对照组比较差异非常显著 (P <0 .0 1 )。损毁海马内NA能神经支配后 ,灸疗的这一作用被部分阻断 ,上述指标与海马损毁组比较差异不显著 (P >0 .0 5 )。结果提示 ,海马可能是艾灸治疗信息中枢整合的一个重要环节 ,海马 HPA系统是灸疗抗炎与免疫调节作用中一条重要的神经体液性途径。
The study was to determine the effect of damage to noradrenergic nerves in hippocampus on the action of anti-inflammatory and immune regulation of moxibustion,thus to probe into the mechanism of moxibustion in central regulation.Models of adjuvant arthritis(AA) in rats were made,and microinjection of 6-hydroxydopamine (6-OHDA) into hippocampus was given, and then changes in vola circumference, index of thymus and spleen,IL-6,IL-2 after moxibustion were observed. Results show that moxibustion group present obvious effects of anti-inflammatory and immune regulation(P<0.01 comparing with control group),and the effects were partly blocked by the damage to noradrenergic nerves in hippocampus (P>0.05).It indicates that hippocampus may be an important portion relating to the central information integration of moxibustion treatment,and hippocampus-hypothalamic-pituitary-adrenocortical(HPA) system may be a neurohumoral route in the action of anti-inflammatory and immune regulation of moxibustion.
出处
《针刺研究》
CAS
CSCD
2000年第3期184-187,共4页
Acupuncture Research
基金
国家自然科学基金!课题 (No.396 70 90 3)
