摘要
目的监测癫痫儿童丙戊酸药物浓度,探讨影响丙戊酸(VPA)血药浓度的因素,为临床合理用药提供参考。方法采用酶增强免疫分析法(EMIT)法测定癫痫患儿丙戊酸药物浓度,并对结果进行分析。结果男性患儿有1 643例,占61.3%,女性患儿1 036例,占38.7%;各年龄组中,<3 a组有1 009例,占37.7%,比例最大;丙戊酸与卡马西平联用,丙戊酸药物浓度降低,联用前后,丙戊酸的平均浓度值有显著性差异(P<0.05);所监测的例数中,50～100μg/mL浓度组分布例数最多,占56.4%(1 511例),平均浓度(69.78±12.96)μg/mL,>100μg/mL浓度组有效率最高,占95.1%(162例),平均浓度(114.32±12.54)μg/mL。结论儿童体内丙戊酸代谢差异显著,不能仅仅以血药浓度为依据,应综合各方面因素,以确保患者用药安全、有效和个体化治疗。
Objective To monitor the Valproic acid concentration in children with epilepsy, to investigate the influencing elements on the Valproie acid concentration, and so as to provide reference for the clinical rational drug application. Methods Valproie acid concentrations were detected by enzyme-multiplied immunoassay technique （EMIT）, and the data were statistically analyzed. Results Boys had I 643 tests （61.3%）, and girls had 1 036 tests （38.7%）. As in different ages, the 〈3 years group had the maximum ratio, accounted for 37.7% （1 009 tests）. Valproic acid concentration decreased when combined with Carbamazepine, and the average concentrations of valproic acid were significantly different before and after the use of Carbamazepine （P 〈 O. 05 ）. The 50 - 100 Fg/mL group had the maximum ratio, accounted for 56.4% （1 511 tests）, and the average concentration was （69.78 ± 12.96） μg/mL. The 〉 100 μg/mL group has the highest effective rate, accounted for 95.1% （162 tests） , and the average concentration was （114.32 ± 12.54） μg/mL. Conclusion Children have significant metabolic differences. Individual treatment will be safe and effective based on the consideration of integrated elements besides drug concentration.
出处
《今日药学》
CAS
2013年第6期364-366,369,共4页
Pharmacy Today
