摘要
目的探讨艾迪注射液在治疗局部晚期鼻咽癌患者放化疗期间癌症相关性乏力（CRF）中的作用。方法2011年12月至2012年5月我院收治的合并有乏力症状的80例Ⅲ～ⅣB期鼻咽癌患者，均采取同步放化疗后序贯3周期以铂类为主的化疗。采用随机数字表法分为两组，一组40例在治疗同时静脉滴注艾迪注射液（治疗组），另一组40例仅常规治疗（对照组）；依据简明乏力评估量表（BFI）于治疗前（基线值）、治疗第8周、第20周做乏力问卷评分，比较两组患者乏力程度的变化及Ⅲ～Ⅳ度不良反应的发生情况。结果治疗第8周时，两组CRF无明显差异（Х^2=1．758，P=0．32），治疗第20周时，治疗组较对照组患者CRF明显改善；治疗组Ⅲ～Ⅳ度不良反应发生率也明显低于对照组。结论艾迪注射液可以改善Ⅲ～ⅣB期鼻咽癌患者放化疗期间的CRF程度，并能有效降低Ⅲ～Ⅳ度骨髓抑制、口腔黏膜炎及胃肠道反应的发生率。
Objective To investigate the effectiveness of disodium Aidi injection for cancer-related fatigue in nasopharyngeal carcinoma patients of Ⅲ-Ⅳ B stage undergoing radiotherapy and chemotherapy. Methods Eighty nasopharyngeal carcinoma patients of Ⅲ-Ⅳ B stage with fatigue symptoms from December 2011 to May 2012 in our hospital were divided into two groups. All patients received treatment of sequential 3 cycles with platinum-based chemotherapy after concurrent chemoradiation. One group of 40 patients also received intravenous infusion of disodium Aidi injection （ experimental group）, the other group of 40 patients only received conventional therapy （ control group）. Brief fatigue inventory （BFI） questionnaires data were collected at baseline, the eighth week and the twentieth week after treatment. The changes of fatigue severity and the occurrence of Ⅲ-Ⅳ degree adverse reactions in the two groups were compared . Results At the eighth week, the improvement in fatigue severity was not significantly different between two groups （ Х^2 = 1. 758, P = 0. 32）. However, significant improvement in cancer-related fatigue of experimental group was found than that of control group at the twentieth week（ X2 = 8.12, P = 0. 005）. The Ⅲ-Ⅳ degree adverse reactions of experimental group were significantly lower than that of control group . Conclusion Disodium Aidi injection combined with radiotherapy and chemotherapy can improve the cancer-related fatigue of nasopharyngeal carcinoma patients of Ⅲ-ⅣB stage and it can also reduce the incidence rate of Ⅲ-Ⅳ degree adverse reactions.
出处
《国际肿瘤学杂志》
CAS
2013年第7期549-551,共3页
Journal of International Oncology
关键词
鼻咽肿瘤
疲劳
艾迪注射液
Nasopharyngeal neoplasms
Fatigue
Disodium Aidi injection
