摘要
目的观察网络游戏成瘾青少年静息态下大脑局部区域低频振荡振幅的变化。方法采用低频振荡振幅分析方法，通过静息态功能磁共振数据处理工具包比较分析网络游戏成瘾者（n=26）和正常对照组（n=23）静息态下局部脑区自发神经活动的差异。结果与正常对照组相比，成瘾组在前扣带回、左侧中扣带回、双侧尾状核、伏隔核、双侧旁海马、右侧苍白球和右侧脑岛等脑区处的低频振荡振幅值差异显著性增强（FWE校正后P〈0．05）。右侧旁海马（r=0．4437，P=0．0232）和右侧尾状核（r=0．5227，P=0．0062）的低频振荡振幅值与成瘾者的病程呈显著正相关。结论网络游戏成瘾者大脑部分区域表现出了异常的自发神经活动特性，并且可能随着病程加重。
Objective To investigate the characteristic of regional amplitude of low frequency fluctuation （ALFF） in the brain of adolescents with online game addiction during the resting state. Methods The ALFF method was employed to explore the local features of spontaneous brain activity in adolescents with online game addiction （ n = 26） and healthy controls （ n = 23 ） during resting-state by Resting-State fMRI Data Analysis Toolkit. Results Compared with healthy controls, adolescents with online game addiction showed increased ALFF values in the anterior cingulate cortex （ ACC）, left middle cingulate cortex （ MCC）, bilateral caudate, right pallidum, bilater- al parahippocampal gyms, and right insula. It was noteworthy that the ALFF values of the right caudate （ r = 0. 4437, P = 0. 0232） and right parahippocampal gyms （ r = 0. 5227, P = 0. 0062） were positively correlated with the duration of online game addiction. Conclusion The abnormal spontaneous neuronal activity properties during the resting state were revealed in the brain regions of adolescents with online game addiction. And the abnormali- ties may become more significant as the disease progresses.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2013年第7期630-632,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金资助项目（61179019,81101036）
内蒙古自治区自然科学基金资助项目（2012MS0908）
内蒙古科技大学创新基金资助项目（2010NC038）
关键词
网络游戏成瘾
静息态
低频振荡振幅
Online game addiction
Resting state
Amplitude of low frequency fluctuation
