摘要
目的系统评价中医药治疗咳嗽变异性哮喘的临床随机对照试验的文献质量。方法检索2002至2012年有关中医药治疗咳嗽变异性哮喘的RCT文献,按照临床流行病学和循证医学的原则和方法,对方法学,一般情况,疾病诊断及纳入、排除标准,随机方法,盲法,样本含量,疗效判定标准,随访,不良反应及脱落等进行评价。结果纳入52篇文献,出现16种诊断标准。38篇文献无纳入和排除标准的描述。39篇报道了疗效判断标准。纳入的52篇文献中均描述了随机,但仅仅有3篇文献提到具体的随机方法,所有文献均未对随机序列的产生及具体随机步骤进行说明,均未提及随机隐藏。仅有1篇文献采用单盲法。49篇文献未明确说明应用何种统计方法。5篇文献进行了随访,但均未说明随访的时间和随访方式。4篇文献提及不良反应的观察。所有研究均未报道退出与失访情况。结论虽然目前关于中医药治疗咳嗽变异性哮喘临床随机对照文献较多,但研究质量和文献总体水平相对较低,这一领域迫切需要设计严谨的高质量随机对照研究。
Objective： To evaluate the literature quality of clinical studies of TCM for cough variant asthma（CVA）.Methods： The literatures from 2002 to 2012 were searched by means of electronic retrieval.Some indicators were evaluated according to principles and methods of clincial epidemiology and evidence based medicine including methodology,general condition,criteria for diagnosis and assessment of therapeutic effects.Results： 52 literatures were enrolled.There were 16 literatures with diagnostic ctriteria and 38 articles without enroled or excluded criteria.39 literatures mentioned curative standard for therapeutic effects.Only 3 ones mentioned randomization method.All included studies were absence of allocation concealment.1 articles introduced the blinding method.5 literatures had reported follow-up and 4 ones reported adverse reaction.All included studies did not described retreat cases.Conclusion： There were many clinical studies of TCM on CVA.The quality of study and literature is low comparatively.Therefore,the high quality＇s RCTs with strict design are needed urgently in this area.
出处
《中国中医急症》
2013年第8期1291-1292,1359,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
四川省中医药管理局科技专项课题(2012B084)
关键词
咳嗽变异性哮喘
中医药
临床流行病学
循证医学
Cough variant asthma
Traditional Chinese Medicine
Bibliometrics
Evidence based medicine
