摘要
目的:观察替吉奥并顺铂联合三维适形放疗治疗非手术食管癌的近期疗效和毒副反应。方法:将60例非手术食管癌患者随机分为观察组与对照组,每组各30例。观察组予替吉奥加顺铂联合三维适形放疗治疗,21 d为1个周期;替吉奥80 mg/(m2.d),第1～14天,每天分2次口服;顺铂25 mg/(m2.d),第1～3天。所有患者完成2个周期化疗。对照组予单纯三维适形放疗治疗。结果:观察组有效率为86.67%,对照组有效率为63.33%,2组比较有显著性差异(P<0.05)。2组的毒副反应主要为白细胞减少、放射性食管炎和恶心呕吐。同步放化疗的急性毒性高于单纯放疗。结论:替吉奥加顺铂联合三维适形放疗治疗非手术食管癌可以提高疗效,虽毒副反应有所增加,但患者均可耐受。
Objective： To evaluat the efficacy and toxicity of S-1 and cisplatin combined with three dimensional conformal radiotherapy for non-operative esophageal carcinoma.Methods： Sixty patients with non-operative esophageal carcinoma were randomly divided into two groups.The treatment group（n = 30） were treated with S-1 and cisplatin combined with three dimensional conformal radiotherapy.S-1 80 mg /（m2.d） orally bid on day 1-14 and cisplatin 25 mg /（m2.d） iv on day1-3,repeated for 21 days.Allthe patients shoud take it for 2 cycles;The control group（n = 30） was treated with three dimensional conformal radiotherapy alone.Results： Short term effect in the treatment group was 86.67% and in the control group was 63.33%.The short term effectiveness in two groups had statistically significant difference（P 0.05）.The major toxicity was leucopenia,radiation esophagitis,and nausea and vomiting.The major toxicity was higher in the treatment group than in the control group.Conclusion： S-1 and cisplatin combined with three dimensional conformal radiotherapy for non-operative esophageal cancer can improve curative rates.Although toxicity is increased at the same time,all patients can tolerate.
出处
《现代临床医学》
2013年第4期252-254,共3页
Journal of Modern Clinical Medicine
关键词
替吉奥
顺铂
三维适形放疗
食管癌
S-1
cisplatin
three dimensional conformal radiotherapy
oesophageal carcinoma
