摘要
以D-氨基半乳糖盐酸盐为原料,经四步反应合成了2-N-三氯乙氧羰酰氨基-半乳糖对甲苯硫苷(3);3经两步区域选择性乙酰化反应合成了4,6-O-二-乙酰基-2-N三氯乙氧羰酰氨基-2-脱氧-β-D-吡喃半乳糖对甲苯硫苷(总收率70%),其结构经1H NMR和ESI-MS确证。
p-Methylphenyl 2-deoxy-2-trichloroethoxycarbonyl-amino-1-thio-β-D-galactopyranoside（3） was synthesized from D-galactosamine hydrochloride by a four-step reaction.p-Methylphenyl 4,6-di-O-acetyl-2-deoxy-2-trichloroethoxycarbonylamino-1-thio-β-D-galactopyranoside was synthesized by two regioselective acetylation reactions from 3 in total yield of 70%.The structure was confirmed by 1H NMR and ESI-MS.
出处
《合成化学》
CAS
CSCD
北大核心
2013年第4期469-471,475,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(81072574)
长江学者和创新团队发展计划项目(IRT0944)
