摘要
评价甜菊苷的抗高血压作用。方法 :采用动静脉插管术研究甜菊苷静脉注射对清醒及麻醉自发性高血压大鼠和麻醉犬的降血压作用特点。结果 :清醒自发性高血压大鼠甜菊苷 5 0～ 2 0 0mg kg ,iv ,麻醉自发性高血压大鼠甜菊苷 2 5～ 398mg kg ,iv ,麻醉犬甜菊苷 16～ 15 9mg kg ,iv ,均可剂量依赖性地降低收缩压和舒张压 ,降压持续时间延长 ,且降舒张压的作用较收缩压明显。自发性高血压大鼠甜菊苷 6 3～ 2 5 1mg kg ,iv ,犬甜菊苷 40～ 15 9mg kg ,iv ,量效关系明显。结论 :甜菊苷确有降血压作用 ,且降舒张压的作用较降收缩压作用强。
Objective:To evaluate the effect of stevioside against hypertension. Methods:The characterically hypotensive effect of intravascular stevioside on concious and anesthetized spontaneously hypertensive rats was studied. The concious spontaneously hypertensive rats were given intravascular stevioside 50-200 mg/kg, the anesthetized rats 25-398 mg/kg, and the dogs 16-159 mg/kg. Results:The Stevioside reduced SBP and DBP with a dose dependent, the hypertensive duration are extend, and the effect of DBP reduced was superior to that of SBP. The dose-effect relationship was significant in the spontaneous rats received intravascular stevioside 63-251 mg/kg and the dogs received 40-159 mg/kg. Conclusion:Stevioside has exactly hypotensive effect, its effect of DBP reduced is superious to that of SBP reduced.
出处
《医药导报》
CAS
2000年第3期205-206,共2页
Herald of Medicine
基金
国家新药研究基金资助项目! (基金编号CND 90 12 )
关键词
高血压
甜菊苷
量效关系
降压关系
Hypertension Stevioside Rat/hypertensive Dog Dose-effect relationship
