摘要
目的观察高通量血液透析联合左卡尼汀(L-carnitine)对尿毒症难治性贫血的治疗效果。方法将56例伴有难治性贫血的维持性血液透析(maintance hemodialysis,MHD)患者随机分为4组:普通透析组(14例)行普通血液透析治疗,每周3次;左卡尼汀组(14例)在普通血液透析基础上给予左卡尼汀1 g,每周3次;高通量透析组(14例)行高通量血液透析,每周3次;高通量透析加左卡尼汀组(14例)在高通量透析基础上给予左卡尼汀1 g,每周3次。治疗3、6个月后查血常规、生化指标,进行统计学分析。结果普通透析组和左卡尼汀组对患者的贫血没有改善;高通量透析组和高通量透析加左卡尼汀组贫血指标改善,与对照组比较有统计学意义(P<0.05);高通量透析加左卡尼汀组与高通量组比较疗效显著,有统计学意义(P<0.05)。结论 4组中高通量透析联合左卡尼汀组能有效治疗尿毒症患者难治性贫血。
Objective To study the effect of high -flux hemodialysis combined with levocarnitine on uremic pationts with refractory anemia. Methods Fifty - six patients with refractory anemia in maintenance hemodialysis were randomly divided into 4 groups： normal group （ 14 cases） underwent conventional hemodialysis, 3 times a week; L -earnitine group （14 cases） was given levocarnitine 1 g on common hemodialysis basis, 3 times a week; high -flux dialysis group （14 cases） received high - flux hemodialysis ,3 times a week; high -flux hemodialysis plus L -earnitine group （14 cases） was given levoearnitine 1 g on high -flux hemodialysis basis, 3 times a week. Blood routine and biochemical indicators were examined after treatment for 3 and 6 months, and statistical analysis was made. Results The conventional hemo dialysis group and L - carnitine group had no improvement in anemia ; high - flux hemo dialysis group and high- flux hemodialysis plus L- earnitine group improved in anemia, with statistically significant difference, compared with the conventional hemodialysis group （ P 〈 0.05 ） ; high - flux hemodialysis combined with L - carnitine group, compared with high - flux hemodialysis group, had remarkable curative effect, with statistically significant difference （ P 〈 0.05 ）. Conclusion High -flux hemodialysis combined with L- carnitine is effective in the treatment of uremic patients with refractory anemia
出处
《武警医学》
CAS
2013年第7期577-579,共3页
Medical Journal of the Chinese People's Armed Police Force
