摘要
目的 :探讨当归注射液对低氧性肺动脉高压病人内皮素 1(ET 1)、血管紧张肽Ⅱ (AT Ⅱ )、内源性洋地黄 (EDF)和肺血流动力学的影响。方法 :慢性阻塞性肺疾病 (COPD)伴肺动脉高压 60例 ,随机分成 2组 ,每组 30例。当归组 [男性 2 1例 ,女性9例 ;年龄 ( 60±s 7)a]给予 2 5%当归注射液 2 50mL静脉滴注 ,qd× 10d ;对照组 [男性 2 0例 ,女性10例 ;年龄 ( 60± 8)a]给予静脉滴注 5%葡萄糖注射液 2 50mL ,qd× 10d。结果 :当归治疗后ET 1,ATⅡ和EDF分别降低 ( 2 0± 6) % ,( 36± 9) %和 ( 38± 11) % ,平均肺动脉压和肺血管阻力也降低 ( 17±5) %和 ( 2 7± 8) % ,与对照组相比均差异有显著意义或非常显著意义 (P <0 .0 5或P <0 .0 1)。结论 :当归能减少COPD伴肺动脉高压病人机体ET 1,AT Ⅱ和EDF的合成和释放 ,使肺动脉压降低 ,改善肺循环。
AIM:To study the effects of Angelica sinensis injection on endothelin-1(ET-1),angiotensinⅡ(AT-Ⅱ),endogenous digitalis-like factor (EDF) and pulmonary hemodynamics in the patients with hypoxic pulmonary hypertension (COPD). METHODS: Sixty patients with chronic obstructive pulmonary disease (COPD) complicated pulmonary hypertension were randomly divided into two groups. The Angelica sinensis injection group of 30 patients [M21,F9;age(60 ± s 7) a] were treated with 25% Angelica sinensis injection 250 mL, iv drip, qd, for 10 d. The control group of 30 patients [M20,F10;age(60±8) a] were received 5% glucose injection 250 mL, iv drip, qd for 10 d. RESULTS: The levels of blood ET-1,ATⅡ,EDF,mean pulmonary arterial pressure (MPAP) and pulmonary vascular resistance (PVR) were decreased by (20±6)%,(36±9)%,(38±11)% and (17±5)%,(27±8)% respectively in the Angelica sinensis injection group. There were significant differences compared with the control group ( P <0.05 or P <0.01). CONCLUSION: Angelica sinensis can inhibit synthesis and release of ET-1, AT-Ⅱ and EDF of blood, decrease pulmonary arterial pressure and improve pulmonary circulation in the patients with COPD complicated pulmonary hypertension.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2000年第6期467-469,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
低氧性肺动脉高压
血管收缩肽
当归注射液
Angelica sinensis
obstructive lung diseases
endothelins
angiotensinⅡ [
