摘要
目的探讨乳腺癌患者新辅助化疗磁共振(MRI)动态增强曲线和弥散加权成像(DWI)检查与Ki67表达的关系。方法经病理证实的Ki67阳性乳腺癌患者26例行MRI动态增强及DWI,判断动态增强曲线的类型和测量病灶表观弥散系数(ADC)值。结果新辅助化疗后Ki67表达降低(P<0.05)。时间信号曲线的类型与Ki67表达有关(P<0.05);时间信号曲线与ADC值无关(P>0.05)。结论 Ki67的表达与乳腺癌局部的血流供应有关,MRI检查可以初步判断肿瘤的增殖和血流状态。
Objective To explore the relationship between Ki67 expression and changes of dynamic contrast-enhanced magnetic resonance imaging （MRI） and diffusion weighted imaging （DWI） in patients with breast cancer treated with neoadjuvant chemotherapy. Methods Tweenty-six cases of Ki67-positive patients with breast cancer received dynamic contrast-enhanced MRI and DWI, they were used to determine the dynamic contrast-enhanced curves＇ type of lesions and to measure the apparent digestibility coefficient （ADC） values. Results Ki67 expression was reduced after neoadjuvant chemotherapy （ P 〈 0.05 ）. The type of time-signal curve was related with the ki67 expression （ P 〈 0.05 ）, and had no relation with the ADC values （ P 〉 0.05 ）. Conclusion Ki67 expression is associated with local blood supply in breast cancer, and the tumor proliferation and blood flow can be observed partially by MRI.
出处
《肿瘤基础与临床》
2013年第4期328-330,共3页
journal of basic and clinical oncology
关键词
KI67
乳腺癌
磁共振动态增强
弥散加权成像
Ki67
breast cancer
dynamic contrast-enhanced magnetic resonance imaging
diffusion weighted imaging
