摘要
目的:观察和评价采用卷曲霉素、力克肺疾、左氧氟沙星、吡嗪酰胺、乙胺丁醇联合方案治疗耐多药肺结核患者的疗效。方法:将耐多药肺结核164例随机分为实验组82例和对照组82例,实验组化疗方案:卷曲霉素、力克肺疾、左氧氟沙星、吡嗪酰胺、乙胺丁醇;对照组化疗方案:丁胺卡那霉素、丙硫异烟胺、氧氟沙星、吡嗪酰胺、乙胺丁醇,疗程均为24个月,比较两组疗效。结果 :实验组痰菌阴转(80.5%)明显优于对照组(61.0%),差异有统计学意义(P<0.05);胸部X线病灶变化情况:实验组有效率为97.6%,对照组为73.2%,二者差异有统计学意义(P<0.05)。结论:采用卷曲霉素、力克肺疾、左氧氟沙星、吡嗪酰胺、乙胺丁醇联合方案治疗耐多药肺结核疗效确切,药物不良反应低,建议临床推广应用。
Objective：Aim To observe the curative effects of combination therapy containing capreomycin,dipasic,levofloxacin,pyrazinamide and ethambutol on multi-drug resistant tuberculosis.Methods：A total of 164cases with multi-drug resistant tuberculosis were randomly divided into experimental group and control group by half.Patients in experimental group had capreomycin,dipasic,levofloxacin and pyrazinamide,while patients in control group had amikacin,protionamide,ofloxacin,pyrazinamide,and ethambutol.The course of treatment was 24months.And the efficacy was observed and compared.Results：The sputum negative conversion rate of the experimental group was 80.5%,which was obviously superior to that of the control group（61.0%）（P0.05）.Chest X-ray showed efficacy of experimental group was 97.6%,while the control group was 73.2%,with significant difference between two groups（P 0.05）.Conclusions：The combination therapy of capreomycin,dipasic,levofloxacin,pyrazinamide and ethambutol is effective on treating multi-drug resistant tuberculosis.It is of low adverse reaction,and is worthy clinical application.
出处
《海南医学院学报》
CAS
2013年第9期1264-1266,共3页
Journal of Hainan Medical University
基金
广东省汕头市科技攻关重点项目(2011137)~~
关键词
耐多药肺结核
药物疗法
卷曲霉素
Capreomycin
Multi-drug resistance tuberculosis
Drug therapy
