摘要
目的:探讨GnRH拮抗剂应用于FSH促排卵人工授精周期中的作用及临床价值。方法:全面检索数据库,获得相关临床随机对照(RCT)文献9篇,共纳入患者1 771名,其中拮抗剂组858名,对照组913名,对其进行质量评价、筛选和异质性检验,应用Rev Man5.0软件对各研究的原始结果进行统计处理。结果:拮抗剂组与对照组相比,周期妊娠率、多胎率、早期流产率、周期取消率无明显差异,卵泡过早黄素化显著降低(17.2%vs 3.6%),差异具有统计学意义(P<0.05)。结论:在FSH促排卵的IUI中加用GnRH拮抗剂能有效地抑制内源性LH水平,显著降低卵泡黄素化,适用于既往周期有明确黄素化史的患者。
Objective：To assess the effects and clinical value of GnRH antagonist in FSH stimulated intrauterine insemination（IUI）cycles.Methods：Databases including the Medline,EMBASE,Cochrane library,Clinical trial were searched for prospective trials and 9random control trials（RCT）were reviewed in this meta-analysis by Rev Man 5.0soft ware.858patients who were administered GnRH antagonist and 913conservatively treated patients who served as control subjects were included.Result：Premature luteinzation was significant lower in GnRH antagonist cycles compared to the control cycles（17.2%vs.3.6%,P0.05）,while there were no statistical differences in pregnancy rate（PR）,multi pregnancy rate,miscarry rate,and cycle cancel rate between two groups in evaluation criteria.Conclusion：GnRH antagonist in FSH/IUI cycles may be beneficial by decreasing premature luteinzation rate safety and efficiently,which may be an alternative treatment option for subjects with previous proven luteinization.
出处
《海南医学院学报》
CAS
2013年第9期1180-1184,1188,共6页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210773)~~
