摘要
目的研究白花丹素在小鼠体内的药代动力学特点和组织分布特性,提供白花丹素在小鼠体内的药动学模型及参数。方法小鼠单剂量尾静脉注射白花丹素后,采用HPLC-DAD法测定血浆及组织中白花丹素的浓度。结果小鼠尾静脉注射白花丹素后,其血药浓度随时间的变化过程符合二室模型(权重因子=1),体内消除半衰期为9.44 min,曲线下面积为17.16(mg/L).min。在各脏器组织中均有分布,其中肝脏分布最多,2 min时肝中白花丹素含量可达为17.314μg/g,其他组织含量较低。结论白花丹素在小鼠体内药动学过程符合二室模型,药物进入体内分布迅速,消除速率也较快。
Objective To study the pharmacokineties and tissue distribution of plumbagin in mice, and investigate pharmacokinetic model and parameters. Methods After intravenous administration with single dose to mice, high- performance liquid chromatographic with DAD method was used to determine the concentration of plumbagin in plasma and tissues of mice. Results The plasma drug concentration-time curve of plumbagin conformed to two-compartment model and the elimination half-life was 9.44 min, AUC was 17.16 （mg/L） · min. The content of plumbagin was high in liver, and it was lower in the other tissues. The content of plumbagin in liver was 17. 314 μg/g at 2 min. Conclusion Plumbagin is fit to two-compartment model in mice. The plumbagin is distributed and eliminated quickly after i. v. administration.
出处
《今日药学》
CAS
2013年第7期413-417,共5页
Pharmacy Today
关键词
白花丹素
血药浓度
组织分布
药代动力学
plumbagin
plasma drug concentration
tissue distribution
pharmacokinetics
