摘要
目的探讨缺铁性贫血患者血清Hepcidin和红细胞CD71的变化及其意义。方法分别应用酶联免疫吸附法和流式细胞仪检测50例缺铁性贫血患者(病例组)和20例健康体检者(对照组)血清Hepcidin和红细胞CD71水平。结果病例组与对照组比较血清Hepcidin明显降低(P<0.01),红细胞CD71明显升高(P<0.01)。中度贫血组和重度贫血组血清Hepcidin与轻度贫血组比较明显降低(P均<0.05),重度贫血组红细胞CD71与轻度贫血组比较明显升高(P<0.05)。病例组血清Hepcidin与血红蛋白(Hb)、红细胞平均体积(MCV)、平均血红蛋白含量(MCH)、平均血红蛋白浓度(MCHC)和血清铁蛋白(SF)呈正相关(P均<0.05),与红细胞分布宽度(RDW)呈负相关(P<0.01),与网织红细胞百分比(RET%)和红细胞CD71无相关性(P均>0.05);红细胞CD71与Ret%呈正相关(P<0.01),与HB、MCV、MCH、MCHC、SF和RDW无相关性(P均>0.05)。结论缺铁性贫血患者血清Hepcidin降低和红细胞CD71升高,其变化程度与疾病严重程度相关。
Objective To investigate the changes of serum Hepcidin and erythrocyte CD71 in iron deficiency anemia patients and analyse their clinical significanees. Methods Serum Hepcidin and erythrocyte CD71 in 50 patients with iron deficiency anemia （disease group） and 20 healthy subjects （control group） were detected by enzyme -linked immunosorbent assay and flow eytometry respectively. Results Compared with control group, the serum Hepcidin in disease group was significantly decreased （ P 〈 0.01 ）, and erythrocyte CD71 was obviously increased （P 〈 O. O1 ）. The serum Hepcidin in moderate anemia group and severe anemia group was lower than mild anemia group （P 〈0.05） , and erythrocyte CDT1 in severe anemia group was higher than mild anemia group （P 〈 0.05）. Hepcidin in disease group was positively correlated to hemoglobin （HB） , mean corpuscular volume （MCV） , mean corpuscular hemoglobin （MCH） , mean corpuscular hemoglobin concentration （MCHC） and serum ferritin （SF） respectively （P all 〈 0.05 ） and negatively to red cell distribution width （RDW） （ P 〈 0.01 ）, but not to retieulocyte rate （ Ret% ） and erythroeyte CD71 （ P all 〉 0.05 ）. Erythrocyte CD71 in disease group was associated with Ret% positively （P 〈 0.01 ） , but not with HB, MCV, MCH, MCHC, SF and RDW （P all 〉 0.05）. Conclusion Serum Hepeidin is decreased and erythrocyte CD71 is increased in iron deficiency anemia patients and both of them are correlated with the severity of disease.
出处
《医学研究杂志》
2013年第8期126-129,共4页
Journal of Medical Research
基金
2011年蚌埠医学院院级科研课题计划项目(BY1057)
