摘要
背景与目的：上皮钙黏蛋白（E-cadherin，E-cad）作为一种关键的结构蛋白对正常的细胞极性、上皮形态和细胞分化非常重要。最近有研究表明E-cad基因启动子区域-160C／A基因多态性与鼻咽癌（nasopharyngeal carcinoma，NPC）的易感性有关。本研究旨在评价中国汉族人群中NPC危险性和E—cad基因启动子-160C／A位点多态性的关系。方法：选取303例明确诊断为NPC的患者为实验组，同时选取318位健康志愿者为对照组。采用TaqMan探针技术检测启动子区域-160C／A位点的单核苷酸多态性。结果：按性别和年龄调整后，实验组E—cad基因启动子-160C／A位点A／A基因型危险性显著高于对照组（调整后OR=2．09，95％CI：1．03-4．22，P=0．04）。按性别分层后，女性NPC患者中A／A基因型危险性显著高于对照组（OR=7．57，95％CI：1．57-36．47，P=0．012）。此外，与NPC患者中男性A／A基因型比对，女性A／A基因型具有更高的患病风险（OR=2．66，95％CI：1．14-6．20，P=0．024）。结论：E-cad基因启动子-160C／A位点的A／A基因型是中国汉族人群患NPC的危险因素之一，尤其对于女性患者尤为显著。
Background and purpose： The E-cadherin as a pivotal structural protein is important for cellular polarity and maintainance of normal tissue morphology and cellular differentiation. Recently some study investigated the impact of the C/A genetic polymorphism at -160 from the site of the E-cadherin gene promoter on susceptibility in NPC. To evaluate the association of the E-cadherin gene promoter -160 C/A single nucleotide polymorphism （SNP） and nasopharyngeal carcinoma risk in a Chinese population, we designed a hospital-based case-control study. Methods： Subjects included in this study were 303 patients definitely diagnosed with NPC, and 318 matched healthy controls. We used TaqMan Probe method for analyzing polymorphism. Results： The A/A genotype was associated with increased risk of NPC after being adjusted for age and gender （adjusted OR=2.09, 95%CI： 1.03-4.22, P=0.04）. When 2 gender groups were analysed respectively, female group with A/A genotypes showed a higher risk （OR=7.57, 95%CI： 1.57- 36.47, P=-0.012）. Besides, among NPC patients compared with males A/A genotype, females with A/A genotype had a significant risk（OR=2.66, 95%CI： 1.14-6.20, P=-0.024）. Conclusion： The A/A genotype of E-cadherin promoter -160 C/ A might he genetic risk factor for NPC, especially female patients.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2013年第7期512-518,共7页
China Oncology
关键词
上皮钙黏蛋白
单核苷酸多态性
鼻咽癌
E-cadherin
Single nucleotide polymorphism
Nasopharyngeal carcinoma
